Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections

Oliviero, Barbara; Cerino, Antonella; Varchetta, Stefania; Paudice, Enrica; Pai, Somnath; Ludovisi, Serena; Zaramella, Marco; Michelone, Giuseppe; Pugnale, Paolo; Negro, Francesco; Barnaba, Vincenzo; Mondelli, Mario U

doi:10.1016/j.jhep.2010.10.016

Scientific article

English

Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections

ContributorsOliviero, Barbara; Cerino, Antonella; Varchetta, Stefania; Paudice, Enrica; Pai, Somnath; Ludovisi, Serena; Zaramella, Marco; Michelone, Giuseppe; Pugnale, Paolo; Negro, Francesco; Barnaba, Vincenzo; Mondelli, Mario U

Published inJournal of hepatology, vol. 55, no. 1, p. 53-60

Publication date2011

Abstract

Chronic microbial infections are frequently associated with B-cell activation and polyclonal proliferation, potentially leading to autoimmunity and lymphoproliferative disorders. We assessed B-cell phenotype and function in chronic hepatitis B (HBV) and chronic hepatitis C (HCV) virus infection.

Keywords

Adolescent
Adult
Aged
B-Lymphocytes/immunology/pathology
Base Sequence
Case-Control Studies
Cell Differentiation
Cell Proliferation
Female
Hepacivirus/genetics
Hepatitis B, Chronic/immunology/pathology
Hepatitis C, Chronic/immunology/pathology/virology
Humans
Immunophenotyping
Lymphocyte Activation
Male
Middle Aged
RNA, Viral/analysis/genetics
Young Adult

Affiliation

Research group

Etudes et traitement de l'hépatite C et B (554)

Citation (ISO format)

OLIVIERO, Barbara et al. Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections. In: Journal of hepatology, 2011, vol. 55, n° 1, p. 53–60. doi: 10.1016/j.jhep.2010.10.016

Article (Published version)

Identifiers

PID : unige:25224
DOI : 10.1016/j.jhep.2010.10.016
PMID : 21145853

ISSN of the journal0168-8278

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Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections

Chronic microbial infections are frequently associated with B-cell activation and polyclonal proliferation, potentially leading to autoimmunity and lymphoproliferative disorders. We assessed B-cell phenotype and function in chronic hepatitis B (HBV) and chronic hepatitis C (HCV) virus infection.

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