Scientific article
English

CD4+CD25-mTGFbeta+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma

Published inInternational immunology, vol. 23, no. 1, p. 17-27
Publication date2011
Abstract

Intranasal administration of high amount of allergen was shown to induce tolerance and to reverse the allergic phenotype. However, mechanisms of tolerance induction via the mucosal route are still unclear.

Keywords
  • Administration, Intranasal
  • Allergens/administration & dosage/immunology
  • Animals
  • Asthma/immunology/therapy
  • Bronchoalveolar Lavage Fluid/immunology
  • CD4-Positive T-Lymphocytes/immunology
  • Cell Proliferation
  • Cytokines/biosynthesis
  • Desensitization, Immunologic/methods
  • Drug Evaluation, Preclinical
  • Immune Tolerance
  • Interleukin-2 Receptor alpha Subunit/metabolism
  • Lung/immunology
  • Lymph Nodes/immunology
  • Mice
  • Mice, Inbred BALB C
  • Ovalbumin/administration & dosage/immunology
  • T-Lymphocytes, Regulatory/immunology
  • Th1 Cells/immunology/metabolism
  • Th2 Cells/immunology
  • Transforming Growth Factor beta/metabolism
Citation (ISO format)
PELLATON-LONGARETTI, Céline et al. CD4+CD25-mTGFbeta+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma. In: International immunology, 2011, vol. 23, n° 1, p. 17–27. doi: 10.1093/intimm/dxq453
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0953-8178
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2downloads

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Update14/03/2023 19:54:54
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