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Title

CD4+CD25-mTGFbeta+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma

Authors
Pellaton-Longaretti, Céline
Boudousquié, Caroline
Barbier, Nathalie
Sauty, Alain
Spertini, François
Published in International Immunology. 2011, vol. 23, no. 1, p. 17-27
Abstract Intranasal administration of high amount of allergen was shown to induce tolerance and to reverse the allergic phenotype. However, mechanisms of tolerance induction via the mucosal route are still unclear.
Keywords Administration, IntranasalAllergens/administration & dosage/immunologyAnimalsAsthma/immunology/therapyBronchoalveolar Lavage Fluid/immunologyCD4-Positive T-Lymphocytes/immunologyCell ProliferationCytokines/biosynthesisDesensitization, Immunologic/methodsDrug Evaluation, PreclinicalImmune ToleranceInterleukin-2 Receptor alpha Subunit/metabolismLung/immunologyLymph Nodes/immunologyMiceMice, Inbred BALB COvalbumin/administration & dosage/immunologyT-Lymphocytes, Regulatory/immunologyTh1 Cells/immunology/metabolismTh2 Cells/immunologyTransforming Growth Factor beta/metabolism
Identifiers
PMID: 21123830
Full text
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Structures
Research group Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182)
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(ISO format)
PELLATON-LONGARETTI, Céline et al. CD4+CD25-mTGFbeta+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma. In: International Immunology, 2011, vol. 23, n° 1, p. 17-27. https://archive-ouverte.unige.ch/unige:25205

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Deposited on : 2013-01-09

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