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Title

Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis

Authors
Salliot, Carine
Katchamart, Wanruchada
Lu, Yan
Sun, Ye
Bombardier, Claire
Keystone, Edward
Published in Annals of the Rheumatic Diseases. 2011, vol. 70, no. 2, p. 266-71
Abstract The availability of increasing numbers of biological agents for the treatment of rheumatoid arthritis (RA) offers several therapeutic options. While all biologicals have proven effective in trials, very limited direct comparisons are available. The objective of the present work was to compare the efficacy of biologicals (anti-tumour necrosis factor (TNF) agents, rituximab, abatacept, tocilizumab) in patients with RA with active disease and (i) an inadequate response (IR) to methotrexate (IR-MTX), (ii) an IR to anti-TNF agents (IR-anti-TNFs) using indirect comparisons.
Keywords Antibodies, Monoclonal, Murine-Derived/therapeutic useAntirheumatic Agents/therapeutic useArthritis, Rheumatoid/drug therapyDrug Therapy, CombinationHumansMethotrexate/therapeutic useTreatment OutcomeTumor Necrosis Factor-alpha/antagonists & inhibitors
Identifiers
PMID: 21097801
Full text
Article (Published version) (297 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Mécanisme de l'inflammation articulaire (44)
Citation
(ISO format)
SALLIOT, Carine et al. Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis. In: Annals of the Rheumatic Diseases, 2011, vol. 70, n° 2, p. 266-71. https://archive-ouverte.unige.ch/unige:25201

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Deposited on : 2013-01-09

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