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Title

Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony

Authors
Adaui, V
Schnorbusch, K
Zimic, M
Gutiérrez, A
Decuypere, S
Vanaerschot, M
De Doncker, S
Maes, I
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Published in Parasitology (Cambridge). 2011, vol. 138, no. 2, p. 183-93
Abstract Evaluation of Leishmania drug susceptibility depends on in vitro Sb(V) susceptibility assays, which are labour-intensive and may give a biased view of the true parasite resistance. Molecular markers are urgently needed to improve and simplify the monitoring of Sb(V)-resistance. We analysed here the gene expression profile of 21 L. braziliensis clinical isolates in vitro defined as Sb(V)-resistant and -sensitive, in order to identify potential resistance markers.
Keywords AnimalsAntimony/pharmacology/therapeutic useCell Culture TechniquesDrug Resistance/geneticsGene Expression ProfilingGenetic PleiotropyGenetic VariationHumansLeishmania braziliensis/classification/drug effects/geneticsLeishmaniasis, Cutaneous/drug therapy/genetics/parasitologyNADH, NADPH Oxidoreductases/genetics/metabolismOrnithine Decarboxylase/genetics/metabolismParasitic Sensitivity Tests
Identifiers
PMID: 20678296
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Research group Groupe Jean-Michel Gaspoz (23)
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ADAUI, V et al. Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony. In: Parasitology (Cambridge), 2011, vol. 138, n° 2, p. 183-93. https://archive-ouverte.unige.ch/unige:25199

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Deposited on : 2013-01-09

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