Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony

Adaui, V; Schnorbusch, K; Zimic, M; Gutiérrez, A; Decuypere, S; Vanaerschot, M; De Doncker, S; Maes, I; Llanos-Cuentas, A; Chappuis, François; Arévalo, J; Dujardin, J-C

doi:10.1017/S0031182010001095

Scientific article

English

Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony

ContributorsAdaui, V; Schnorbusch, K; Zimic, M; Gutiérrez, A; Decuypere, S; Vanaerschot, M; De Doncker, S; Maes, I; Llanos-Cuentas, A; Chappuis, François; Arévalo, J; Dujardin, J-C

Published inParasitology, vol. 138, no. 2, p. 183-193

Publication date2011

Abstract

Evaluation of Leishmania drug susceptibility depends on in vitro Sb(V) susceptibility assays, which are labour-intensive and may give a biased view of the true parasite resistance. Molecular markers are urgently needed to improve and simplify the monitoring of Sb(V)-resistance. We analysed here the gene expression profile of 21 L. braziliensis clinical isolates in vitro defined as Sb(V)-resistant and -sensitive, in order to identify potential resistance markers.

Keywords

Animals
Antimony/pharmacology/therapeutic use
Cell Culture Techniques
Drug Resistance/genetics
Gene Expression Profiling
Genetic Pleiotropy
Genetic Variation
Humans
Leishmania braziliensis/classification/drug effects/genetics
Leishmaniasis, Cutaneous/drug therapy/genetics/parasitology
NADH, NADPH Oxidoreductases/genetics/metabolism
Ornithine Decarboxylase/genetics/metabolism
Parasitic Sensitivity Tests

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de médecine de premier recours

Research groups

Groupe Jean-Michel Gaspoz (23)

Citation (ISO format)

ADAUI, V et al. Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony. In: Parasitology, 2011, vol. 138, n° 2, p. 183–193. doi: 10.1017/S0031182010001095

Article (Published version)

Identifiers

PID : unige:25199
DOI : 10.1017/S0031182010001095
PMID : 20678296

Journal ISSN0031-1820

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Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony

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