Scientific article

Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation

Published inPigment cell & melanoma research, vol. 24, no. 2, p. 282-294
Publication date2011

From the onset of melanocyte specification from the neural crest, throughout their migration during embryogenesis and until they reside in their niche in the basal keratinocyte layer, melanocytes interact in dynamic ways with the extracellular environment of the growing embryo. To recognize and to adhere to their environment, melanocytes depend on heterodimeric cell surface receptors of the family of integrins. In addition to the control of adhesive interactions between melanocytes and the extracellular matrix scaffold secreted by fibroblasts and keratinocytes, the integrin receptors allow cells also to sense the mechanical condition of the extracellular environment, responding by intracellular signaling, triggering cell survival, proliferation or migration events. In this review, we summarize the recently emerged concepts that explain integrin-dependent adhesion and how this adhesion system interfaces with integrin-dependent signaling events. The gained information will help to understand melanocyte behavior in pathological situations such as melanoma growth and metastasis formation.

  • Amino Acid Sequence
  • Animals
  • Cell Adhesion/physiology
  • Cell Movement/physiology
  • Cell Proliferation
  • Cytoskeletal Proteins/chemistry/metabolism
  • Evolution, Molecular
  • Humans
  • Integrins/chemistry/genetics/metabolism
  • Melanocytes/cytology/physiology
  • Melanoma/metabolism/pathology
  • Membrane Proteins/chemistry/metabolism
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Sequence Alignment
  • Signal Transduction
  • Talin/chemistry/metabolism
Citation (ISO format)
PINON, Perrine, WEHRLE-HALLER, Bernhard. Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation. In: Pigment cell & melanoma research, 2011, vol. 24, n° 2, p. 282–294. doi: 10.1111/j.1755-148X.2010.00806.x
Main files (1)
Article (Published version)
ISSN of the journal1755-1471

Technical informations

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