Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

Deblon, Nicolas; Bourgoin, Lucie; Veyrat-Durebex, Christelle; Peyrou, Marion; Vinciguerra, Manlio; Caillon, Aurélie; Maeder Garavaglia, Christine; Fournier, Margot; Montet, Xavier Cédric Rodolphe; Rohner-Jeanrenaud, Françoise; Foti, Michelangelo

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Title		Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
Authors		Deblon, Nicolas Bourgoin, Lucie Veyrat-Durebex, Christelle Peyrou, Marion Vinciguerra, Manlio Caillon, Aurélie Maeder Garavaglia, Christine Fournier, Margot Montet, Xavier Cédric Rodolphe Rohner-Jeanrenaud, Françoise Foti, Michelangelo show all authors [1 - 11]
Published in		British Journal of Pharmacology. 2012, vol. 165, no. 7, p. 2325-40
Abstract		mTOR inhibitors are currently used as immunosuppressants in transplanted patients and as promising anti-cancer agents. However, new-onset diabetes is a frequent complication occurring in patients treated with mTOR inhibitors such as rapamycin (Sirolimus). Here, we investigated the mechanisms associated with the diabetogenic effects of chronic Sirolimus administration in rats and in in vitro cell cultures.
Keywords		Adipose Tissue/drug effects — Animals — Cells, Cultured — Diet, High-Fat/adverse effects — Fatty Liver/prevention & control — Glucose/metabolism — Glucose Clamp Technique — Glucose Intolerance/chemically induced — Glucose Transporter Type 4/metabolism — Immunosuppressive Agents/toxicity — Insulin/metabolism — Insulin Resistance — Male — Muscle Fibers, Skeletal/drug effects/metabolism — Muscle, Skeletal/drug effects/metabolism — Proto-Oncogene Proteins c-akt/metabolism — Rats — Rats, Wistar — Signal Transduction/drug effects — Sirolimus/toxicity — TOR Serine-Threonine Kinases/antagonists & inhibitors/metabolism — Weight Loss/drug effects
Identifiers		DOI: 10.1111/j.1476-5381.2011.01716.x PMID: 22014210
Full text		Article (Published version) (1.7 MB) - Private access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups		Homéostasie métabolique (649) Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949) Obésité et syndrome métabolique (803)
Citation (ISO format)		DEBLON, Nicolas et al. Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. In: British Journal of Pharmacology, 2012, vol. 165, n° 7, p. 2325-40. https://archive-ouverte.unige.ch/unige:25156