Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
Published inBritish journal of pharmacology, vol. 165, no. 7, p. 2325-2340
Publication date2012
Abstract
Keywords
- Adipose Tissue/drug effects
- Animals
- Cells, Cultured
- Diet, High-Fat/adverse effects
- Fatty Liver/prevention & control
- Glucose/metabolism
- Glucose Clamp Technique
- Glucose Intolerance/chemically induced
- Glucose Transporter Type 4/metabolism
- Immunosuppressive Agents/toxicity
- Insulin/metabolism
- Insulin Resistance
- Male
- Muscle Fibers, Skeletal/drug effects/metabolism
- Muscle, Skeletal/drug effects/metabolism
- Proto-Oncogene Proteins c-akt/metabolism
- Rats
- Rats, Wistar
- Signal Transduction/drug effects
- Sirolimus/toxicity
- TOR Serine-Threonine Kinases/antagonists & inhibitors/metabolism
- Weight Loss/drug effects
Citation (ISO format)
DEBLON, Nicolas et al. Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. In: British journal of pharmacology, 2012, vol. 165, n° 7, p. 2325–2340. doi: 10.1111/j.1476-5381.2011.01716.x
Main files (1)
Article (Published version)
Identifiers
- PID : unige:25156
- DOI : 10.1111/j.1476-5381.2011.01716.x
- PMID : 22014210
ISSN of the journal0007-1188