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Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

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Published in British journal of pharmacology. 2012, vol. 165, no. 7, p. 2325-40
Abstract mTOR inhibitors are currently used as immunosuppressants in transplanted patients and as promising anti-cancer agents. However, new-onset diabetes is a frequent complication occurring in patients treated with mTOR inhibitors such as rapamycin (Sirolimus). Here, we investigated the mechanisms associated with the diabetogenic effects of chronic Sirolimus administration in rats and in in vitro cell cultures.
Keywords Adipose Tissue/drug effectsAnimalsCells, CulturedDiet, High-Fat/adverse effectsFatty Liver/prevention & controlGlucose/metabolismGlucose Clamp TechniqueGlucose Intolerance/chemically inducedGlucose Transporter Type 4/metabolismImmunosuppressive Agents/toxicityInsulin/metabolismInsulin ResistanceMaleMuscle Fibers, Skeletal/drug effects/metabolismMuscle, Skeletal/drug effects/metabolismProto-Oncogene Proteins c-akt/metabolismRatsRats, WistarSignal Transduction/drug effectsSirolimus/toxicityTOR Serine-Threonine Kinases/antagonists & inhibitors/metabolismWeight Loss/drug effects
PMID: 22014210
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Research groups Homéostasie métabolique (649)
Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
Obésité et syndrome métabolique (803)
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DEBLON, Nicolas et al. Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. In: British journal of pharmacology, 2012, vol. 165, n° 7, p. 2325-40. doi: 10.1111/j.1476-5381.2011.01716.x https://archive-ouverte.unige.ch/unige:25156

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Deposited on : 2013-01-08

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