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Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis |
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Authors | ![]() | |
Published in | Tropical Medicine & International Health. 2011, vol. 16, no. 1, p. 119-26 | |
Abstract | A critical step before treatment of human African trypanosomiasis (HAT) is the correct staging of the disease. As late stage is established when trypanosomes cross the blood-brain barrier and invade the central nervous system, we hypothesized that matrix metalloproteinases and cell adhesion molecules could indicate, alone or in combination, the disease progression from the first to the second stage of HAT. | |
Keywords | Adolescent — Adult — Aged — Biological Markers/cerebrospinal fluid — Cell Adhesion Molecules/cerebrospinal fluid — Central Nervous System Protozoal Infections/cerebrospinal fluid — Chemokines/cerebrospinal fluid — Disease Progression — Epidemiologic Methods — Female — Humans — Intercellular Adhesion Molecule-1/cerebrospinal fluid — Male — Matrix Metalloproteinase 9/cerebrospinal fluid — Middle Aged — Trypanosoma brucei gambiense/isolation & purification — Trypanosomiasis, African/cerebrospinal fluid/diagnosis — Young Adult | |
Identifiers | PMID: 20958893 | |
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Research group | Groupe de Protéomique biomédicale (635) | |
Citation (ISO format) | HAINARD, Alexandre et al. Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis. In: Tropical Medicine & International Health, 2011, vol. 16, n° 1, p. 119-26. https://archive-ouverte.unige.ch/unige:25128 |