Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis

Hainard, Alexandre; Tiberti, Natalia; Robin, Xavier Arnaud; Ngoyi, Dieudonné M; Matovu, Enock; Enyaru, John C K; Muller, Markus Johann; Turck, Natacha; Ndung'u, Joseph M; Lejon, Veerle; Sanchez, Jean-Charles

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Title		Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis
Authors		Hainard, Alexandre Tiberti, Natalia Robin, Xavier Arnaud Ngoyi, Dieudonné M Matovu, Enock Enyaru, John C K Muller, Markus Johann Turck, Natacha Ndung'u, Joseph M Lejon, Veerle Sanchez, Jean-Charles show all authors [1 - 11]
Published in		Tropical Medicine & International Health. 2011, vol. 16, no. 1, p. 119-26
Abstract		A critical step before treatment of human African trypanosomiasis (HAT) is the correct staging of the disease. As late stage is established when trypanosomes cross the blood-brain barrier and invade the central nervous system, we hypothesized that matrix metalloproteinases and cell adhesion molecules could indicate, alone or in combination, the disease progression from the first to the second stage of HAT.
Keywords		Adolescent — Adult — Aged — Biological Markers/cerebrospinal fluid — Cell Adhesion Molecules/cerebrospinal fluid — Central Nervous System Protozoal Infections/cerebrospinal fluid — Chemokines/cerebrospinal fluid — Disease Progression — Epidemiologic Methods — Female — Humans — Intercellular Adhesion Molecule-1/cerebrospinal fluid — Male — Matrix Metalloproteinase 9/cerebrospinal fluid — Middle Aged — Trypanosoma brucei gambiense/isolation & purification — Trypanosomiasis, African/cerebrospinal fluid/diagnosis — Young Adult
Identifiers		DOI: 10.1111/j.1365-3156.2010.02642.x PMID: 20958893
Full text		Article (Published version) (228 Kb) - Limited access to UNIGE
Structures		Faculté des sciences / Département d'informatique Centres et instituts / Centre universitaire d'informatique Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research group		Groupe de Protéomique biomédicale (635)
Citation (ISO format)		HAINARD, Alexandre et al. Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis. In: Tropical Medicine & International Health, 2011, vol. 16, n° 1, p. 119-26. https://archive-ouverte.unige.ch/unige:25128