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Scientific article
English

Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis

Published inTM & IH. Tropical medicine and international health, vol. 16, no. 1, p. 119-126
Publication date2011
Abstract

A critical step before treatment of human African trypanosomiasis (HAT) is the correct staging of the disease. As late stage is established when trypanosomes cross the blood-brain barrier and invade the central nervous system, we hypothesized that matrix metalloproteinases and cell adhesion molecules could indicate, alone or in combination, the disease progression from the first to the second stage of HAT.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Biological Markers/cerebrospinal fluid
  • Cell Adhesion Molecules/cerebrospinal fluid
  • Central Nervous System Protozoal Infections/cerebrospinal fluid
  • Chemokines/cerebrospinal fluid
  • Disease Progression
  • Epidemiologic Methods
  • Female
  • Humans
  • Intercellular Adhesion Molecule-1/cerebrospinal fluid
  • Male
  • Matrix Metalloproteinase 9/cerebrospinal fluid
  • Middle Aged
  • Trypanosoma brucei gambiense/isolation & purification
  • Trypanosomiasis, African/cerebrospinal fluid/diagnosis
  • Young Adult
Citation (ISO format)
HAINARD, Alexandre et al. Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis. In: TM & IH. Tropical medicine and international health, 2011, vol. 16, n° 1, p. 119–126. doi: 10.1111/j.1365-3156.2010.02642.x
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ISSN of the journal1360-2276
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