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Copper-Catalyzed Enantioselective Synthesis of Axially Chiral Allenes

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Published in Organic Letters. 2012, vol. 14, no. 23, p. 5880-5883
Abstract A simple copper-catalyzed enantioselective synthesis of axially chiral chloroallenes from the propargylic dichlorides is reported, employing a catalytic amount of easily prepared SimplePhos ligand. Exclusive formation of the desired allenes was observed with good enantioselectivities (ee’s 62–96%). Further transformations to trisubstituted allenes or terminal alkynes with a propargylic quaternary carbon center keep a high level of enantiopurity.
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Other version: http://pubs.acs.org/doi/abs/10.1021/ol302790e
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LI, Hailing et al. Copper-Catalyzed Enantioselective Synthesis of Axially Chiral Allenes. In: Organic Letters, 2012, vol. 14, n° 23, p. 5880-5883. https://archive-ouverte.unige.ch/unige:25120

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Deposited on : 2013-01-08

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