Persistence of recipient-type endothelium after allogeneic hematopoietic stem cell transplantation

Mueller, Regula J; Stussi, Georg; Puga Yung, Gisella; Nikolic, Milica; Soldini, Davide; Halter, Jörg; Meyer-Monard, Sandrine; Gratwohl, Alois; Passweg, Jakob; Odermatt, Bernhard; Schanz, Urs; Biedermann, Barbara C; Seebach, Jorg Dieter

doi:10.3324/haematol.2010.030288

Scientific article

English

Persistence of recipient-type endothelium after allogeneic hematopoietic stem cell transplantation

ContributorsMueller, Regula J; Stussi, Georg; Puga Yung, Gisella; Nikolic, Milica; Soldini, Davide; Halter, Jörg; Meyer-Monard, Sandrine; Gratwohl, Alois; Passweg, Jakob; Odermatt, Bernhard; Schanz, Urs; Biedermann, Barbara C; Seebach, Jorg Dieter

Published inHaematologica, vol. 96, no. 1, p. 119-127

Publication date2011

Abstract

The possibility that allogeneic hematopoietic stem cell transplantation performed across the ABO blood group-barrier is associated with an increase of graft-versus-host disease, in particular endothelial damage, has not been elucidated so far. For this reason, we investigated the level of endothelial cell chimerism after allogeneic hematopoietic stem cell transplantation in order to delineate the role of hematopoietic stem cells in endothelial replacement.

Keywords

ABO Blood-Group System/metabolism
Adult
Blood Group Incompatibility
Chimerism
Chromosomes, Human, X/genetics
Chromosomes, Human, Y/genetics
Endothelium, Vascular/physiology
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Immunoenzyme Techniques
In Situ Hybridization, Fluorescence
Middle Aged
Neovascularization, Pathologic
Prospective Studies
Tandem Repeat Sequences
Tissue Donors
Transplantation, Homologous
Young Adult
Von Willebrand Factor/metabolism

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Laboratoire d'immunologie translationnelle (856)

Citation (ISO format)

MUELLER, Regula J et al. Persistence of recipient-type endothelium after allogeneic hematopoietic stem cell transplantation. In: Haematologica, 2011, vol. 96, n° 1, p. 119–127. doi: 10.3324/haematol.2010.030288

Article (Published version)

Identifiers

PID : unige:25119
DOI : 10.3324/haematol.2010.030288
PMID : 20934999

ISSN of the journal0390-6078

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Persistence of recipient-type endothelium after allogeneic hematopoietic stem cell transplantation

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