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Title

Isoflurane anaesthesia differentially affects the amphetamine sensitivity of agonist and antagonist D2/D3 positron emission tomography radiotracers: implications for in vivo imaging of dopamine release

Authors
McCormick, Patrick Neil
Wilson, Alan A
Published in Molecular Imaging and Biology. 2011, vol. 13, no. 4, p. 737-46
Abstract Using positron emission tomography in isoflurane-anaesthetised cat, we recently demonstrated that the effect of D-amphetamine (AMPH) was greater on the binding potential (BP(ND)) of the agonist dopamine D2/D3 radiotracer (+)-4-[(11)C]propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1, 4]oxazin-9-ol ([(11)C]-(+)-PHNO) than on that of the antagonist [(11)C]-raclopride, a finding that we were unable to replicate in conscious rat. Herein we tested whether isoflurane differentially affects the AMPH sensitivity of [(11)C]-(+)-PHNO and [(3)H]-raclopride.
Keywords Amphetamine/pharmacologyAnesthesiaAnimalsCatsCerebellum/drug effects/metabolism/radionuclide imagingDopamine/metabolismIsoflurane/administration & dosage/pharmacologyMaleNeostriatum/drug effects/metabolism/radionuclide imagingOxazines/pharmacokinetics/pharmacologyPositron-Emission Tomography/methodsRaclopride/pharmacokinetics/pharmacologyRadioisotopes/pharmacokinetics/pharmacologyRatsRats, Sprague-DawleyReceptors, Dopamine/metabolismReceptors, Dopamine D2/agonists/antagonists & inhibitorsReceptors, Dopamine D3/agonists/antagonists & inhibitorsTime Factors
Identifiers
PMID: 20680481
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Structures
Research group Imagerie de la transmission dopaminergique dans les troubles addictifs (989)
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MCCORMICK, Patrick Neil, GINOVART, Nathalie, WILSON, Alan A. Isoflurane anaesthesia differentially affects the amphetamine sensitivity of agonist and antagonist D2/D3 positron emission tomography radiotracers: implications for in vivo imaging of dopamine release. In: Molecular Imaging and Biology, 2011, vol. 13, n° 4, p. 737-46. https://archive-ouverte.unige.ch/unige:25088

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Deposited on : 2013-01-08

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