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Title

Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice

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Published in PLOS ONE. 2011, vol. 6, no. 9, p. e25442
Abstract Cytokine administration is a potential therapy for acute liver failure by reducing inflammatory responses and favour hepatocyte regeneration. The aim of this study was to evaluate the role of interleukin-1 receptor antagonist (IL-1ra) during liver regeneration and to study the effect of a recombinant human IL-1ra on liver regeneration.
Keywords Alanine Transaminase/metabolismAnimalsCell Cycle Proteins/geneticsCell Proliferation/drug effectsGene Expression Regulation/drug effectsGene Knockout TechniquesHepatectomyHepatocytes/cytology/drug effects/metabolismHumansInterleukin 1 Receptor Antagonist Protein/deficiency/genetics/metabolism/pharmacologyLiver Regeneration/drug effects/geneticsMaleMiceTime Factors
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PMID: 21980458
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Article (Published version) (2.2 MB) - public document Free access
Structures
Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Cultures cellulaires et transplantations (519)
Hépatologie chirurgicale (327)
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SGROI, Antonino et al. Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice. In: PLOS ONE, 2011, vol. 6, n° 9, p. e25442. doi: 10.1371/journal.pone.0025442 https://archive-ouverte.unige.ch/unige:25041

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Deposited on : 2013-01-07

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