Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice

Sgroi, Antonino; Gonelle-Gispert, Carmen; Morel, Philippe; Baertschiger, Reto Marc; Niclauss, Nadja; Mentha, Gilles; Majno, Pietro; Serre Beinier, Véronique; Buehler, Leo Hans

doi:10.1371/journal.pone.0025442

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Title		Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice
Authors		Sgroi, Antonino Gonelle-Gispert, Carmen Morel, Philippe Baertschiger, Reto Marc Niclauss, Nadja Mentha, Gilles Majno, Pietro Serre Beinier, Véronique Buehler, Leo Hans show all authors [1 - 9]
Published in		PloS one. 2011, vol. 6, no. 9, e25442
Abstract		Cytokine administration is a potential therapy for acute liver failure by reducing inflammatory responses and favour hepatocyte regeneration. The aim of this study was to evaluate the role of interleukin-1 receptor antagonist (IL-1ra) during liver regeneration and to study the effect of a recombinant human IL-1ra on liver regeneration.
Keywords		Alanine Transaminase/metabolism — Animals — Cell Cycle Proteins/genetics — Cell Proliferation/drug effects — Gene Expression Regulation/drug effects — Gene Knockout Techniques — Hepatectomy — Hepatocytes/cytology/drug effects/metabolism — Humans — Interleukin 1 Receptor Antagonist Protein/deficiency/genetics/metabolism/pharmacology — Liver Regeneration/drug effects/genetics — Male — Mice — Time Factors
Identifiers		DOI: 10.1371/journal.pone.0025442 PMID: 21980458
Full text		Article (Published version) (2.2 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups		Chirurgie viscérale (104) Chirurgie viscérale (HUG) Cultures cellulaires et transplantations (519) Hépatologie chirurgicale (327)
Citation (ISO format)		SGROI, Antonino et al. Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice. In: PLOS ONE, 2011, vol. 6, n° 9, p. e25442. doi: 10.1371/journal.pone.0025442 https://archive-ouverte.unige.ch/unige:25041