Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice

Sgroi, Antonino; Gonelle-Gispert, Carmen; Morel, Philippe; Baertschiger, Reto Marc; Niclauss, Nadja; Mentha, Gilles; Majno, Pietro; Serre Beinier, Véronique; Buehler, Leo Hans

doi:10.1371/journal.pone.0025442

Article scientifique

Accès libre

Anglais

Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice

Contributeurs/tricesSgroi, Antonino; Gonelle-Gispert, Carmen; Morel, Philippe; Baertschiger, Reto Marc; Niclauss, Nadja; Mentha, Gilles; Majno, Pietro; Serre Beinier, Véronique

; Buehler, Leo Hans

Publié dansPloS one, vol. 6, no. 9, e25442

Date de publication2011

Résumé

Cytokine administration is a potential therapy for acute liver failure by reducing inflammatory responses and favour hepatocyte regeneration. The aim of this study was to evaluate the role of interleukin-1 receptor antagonist (IL-1ra) during liver regeneration and to study the effect of a recombinant human IL-1ra on liver regeneration.

Mots-clés

Alanine Transaminase/metabolism
Animals
Cell Cycle Proteins/genetics
Cell Proliferation/drug effects
Gene Expression Regulation/drug effects
Gene Knockout Techniques
Hepatectomy
Hepatocytes/cytology/drug effects/metabolism
Humans
Interleukin 1 Receptor Antagonist Protein/deficiency/genetics/metabolism/pharmacology
Liver Regeneration/drug effects/genetics
Male
Mice
Time Factors

Structure d'affiliation

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Groupe de recherche

Citation (format ISO)

SGROI, Antonino et al. Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice. In: PloS one, 2011, vol. 6, n° 9, p. e25442. doi: 10.1371/journal.pone.0025442

Article (Published version)

CC BY

Identifiants

PID : unige:25041
DOI : 10.1371/journal.pone.0025442
PMID : 21980458

ISSN du journal1932-6203

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Création03.12.2012 16:39:00

Première validation03.12.2012 16:39:00

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Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice

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