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Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice

ContributorsSgroi, Antonino; Gonelle-Gispert, Carmen; Morel, Philippe; Baertschiger, Reto Marc; Niclauss, Nadja; Mentha, Gilles; Majno, Pietro; Serre Beinier, Véroniqueorcid; Buehler, Leo Hans
Published inPloS one, vol. 6, no. 9, e25442
Publication date2011
Abstract

Cytokine administration is a potential therapy for acute liver failure by reducing inflammatory responses and favour hepatocyte regeneration. The aim of this study was to evaluate the role of interleukin-1 receptor antagonist (IL-1ra) during liver regeneration and to study the effect of a recombinant human IL-1ra on liver regeneration.

Keywords
  • Alanine Transaminase/metabolism
  • Animals
  • Cell Cycle Proteins/genetics
  • Cell Proliferation/drug effects
  • Gene Expression Regulation/drug effects
  • Gene Knockout Techniques
  • Hepatectomy
  • Hepatocytes/cytology/drug effects/metabolism
  • Humans
  • Interleukin 1 Receptor Antagonist Protein/deficiency/genetics/metabolism/pharmacology
  • Liver Regeneration/drug effects/genetics
  • Male
  • Mice
  • Time Factors
Affiliation entities
Research groups
Citation (ISO format)
SGROI, Antonino et al. Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice. In: PloS one, 2011, vol. 6, n° 9, p. e25442. doi: 10.1371/journal.pone.0025442
Main files (1)
Article (Published version)
accessLevelPublic CC BY
Identifiers
Journal ISSN1932-6203
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357downloads

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