Scientific article
Open access

Prevention of bronchial hyperreactivity in a rat model of precapillary pulmonary hypertension

Published inRespiratory research, vol. 12, 58
Publication date2011

The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling pathways (endothelin, nitric oxide, vasoactive intestine peptide (VIP) and prostacyclin) involved in the control of the pulmonary vascular and bronchial tones.

  • Administration, Oral
  • Airway Resistance/drug effects
  • Analysis of Variance
  • Animals
  • Antihypertensive Agents/administration & dosage/pharmacology
  • Blood Pressure/drug effects
  • Bronchial Hyperreactivity/etiology/metabolism/physiopathology/therapy
  • Bronchial Provocation Tests
  • Bronchoconstriction/drug effects
  • Disease Models, Animal
  • Endothelins/metabolism
  • Hypertension, Pulmonary/complications/drug therapy/metabolism/physiopathology
  • Iloprost/pharmacology
  • Infusion Pumps, Implantable
  • Infusions, Parenteral
  • Lung/blood supply/drug effects/metabolism/physiopathology
  • Lung Volume Measurements
  • Male
  • Nitric Oxide/metabolism
  • Phosphodiesterase 5 Inhibitors/pharmacology
  • Piperazines/pharmacology
  • Prostaglandins I/metabolism
  • Purines/pharmacology
  • Pyridines/pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Endothelin/antagonists & inhibitors/metabolism
  • Signal Transduction/drug effects
  • Sulfones/pharmacology
  • Tetrazoles/pharmacology
  • Time Factors
  • Vasoactive Intestinal Peptide/pharmacology
  • Vasodilator Agents/administration & dosage/pharmacology
Citation (ISO format)
HABRE, Walid et al. Prevention of bronchial hyperreactivity in a rat model of precapillary pulmonary hypertension. In: Respiratory research, 2011, vol. 12, p. 58. doi: 10.1186/1465-9921-12-58
Main files (1)
Article (Published version)
ISSN of the journal1465-9921

Technical informations

Creation11/14/2012 7:20:00 PM
First validation11/14/2012 7:20:00 PM
Update time03/14/2023 7:53:30 PM
Status update03/14/2023 7:53:30 PM
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