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Awareness in children: a secondary analysis of five cohort studies

Davidson, A J
Smith, K R
Blussé van Oud-Alblas, H J
Lopez, Ursula
Malviya, S
Bannister, C F
Galinkin, J L
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Published in Anaesthesia. 2011, vol. 66, no. 6, p. 446-54
Abstract Five recent cohort studies have shown a frequency of awareness in paediatric anaesthesia of between 0.2% and 1.2%, but they were not individually large enough to identify risk factors. This study pooled raw data from these five studies to identify factors associated with awareness in children. The outcome of awareness was taken as the cases judged to be most likely awareness cases in each study. Logistic regression was used to identify awareness-associated factors. A combined sample of 4486 anaesthetics revealed 33 cases of awareness. Unadjusted analysis demonstrated weak evidence that nitrous oxide used as an anaesthetic maintenance adjunct was associated with awareness (OR 2.04 (95% CI 0.97-4.33), p=0.06), and some evidence that use of a tracheal tube was associated with awareness (OR 2.78 (95% CI 1.11-6.94), p=0.03). Multivariable regression analysis revealed that nitrous oxide maintenance and use of a tracheal tube were independently associated with awareness (nitrous oxide, OR 2.4 (95% CI 1.08-5.32), p=0.03; tracheal tube, OR 3.0 (95% CI 1.20-7.56), p=0.02).
Keywords AdolescentAnesthesia, General/adverse effectsAnesthetics, Inhalation/adverse effectsChildChild, PreschoolEpidemiologic MethodsFemaleHumansIntraoperative Awareness/epidemiology/etiologyIntubation, Intratracheal/adverse effectsMaleMental RecallNitrous Oxide/adverse effects
PMID: 21501128
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Research group Enfants et hyperréactivité bronchique (69)
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DAVIDSON, A J et al. Awareness in children: a secondary analysis of five cohort studies. In: Anaesthesia, 2011, vol. 66, n° 6, p. 446-54. doi: 10.1111/j.1365-2044.2011.06703.x https://archive-ouverte.unige.ch/unige:25003

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Deposited on : 2013-01-04

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