Increased neuronal nitric oxide synthase dimerisation is involved in rat and human pancreatic beta cell hyperactivity in obesity
ContributorsMezghenna, K; Pomiès, P; Chalançon, A; Castex, F; Leroy, J; Niclauss, N; Nadal, B; Cambier, L; Cazevieille, C; Petit, P; Gomis, R; Berney, Thierry; Gross, R; Lajoix, A D
Published inDiabetologia, vol. 54, no. 11, p. 2856-2866
Publication date2011
Abstract
Keywords
- Animals
- Cells, Cultured
- Dimerization
- Female
- Gene Expression Regulation, Enzymologic
- Humans
- Insulin/metabolism/secretion
- Insulin Resistance
- Insulin-Secreting Cells/drug effects/metabolism/secretion/ultrastructure
- Islets of Langerhans/drug effects/metabolism/secretion/ultrastructure
- Male
- Middle Aged
- Mitochondria/drug effects/metabolism/ultrastructure
- Nitric Oxide Synthase Type I/antagonists & inhibitors/genetics/metabolism
- Obesity/metabolism
- Protein Transport
- RNA, Messenger/metabolism
- Rats
- Rats, Mutant Strains
- Rats, Zucker
- Tissue Culture Techniques
Affiliation entities
Research groups
Citation (ISO format)
MEZGHENNA, K et al. Increased neuronal nitric oxide synthase dimerisation is involved in rat and human pancreatic beta cell hyperactivity in obesity. In: Diabetologia, 2011, vol. 54, n° 11, p. 2856–2866. doi: 10.1007/s00125-011-2264-8
Main files (1)
Article (Published version)
Identifiers
- PID : unige:24994
- DOI : 10.1007/s00125-011-2264-8
- PMID : 21847584
Journal ISSN0012-186X
