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Doctoral thesis
OA Policy
English

Strategies to design push-pull osmotic systems for delivering low and pH-dependent soluble drugs

Contributors

Malaterre, Vincent

Directors

Gurny, Robert; Loggia, N.

Defense date

2009-02-10

Abstract

In the recent years, novel oral drug delivery systems have been recognized as an attractive niche for pharmaceutical industry. Among these systems, controlledrelease formulations have been developed based on their significant advantages over conventional immediate release dosage forms, such as the decrease of dosing frequency, the increase of patient compliance, better dosing patterns, the reduction of side effects, or the maintenance of the drug concentration within a desired range, i.e, an overall improved therapeutic benefit. However, oral controlled release formulations are exposed to changing environment during transit through the GI-tract which may affect their performances e.g. physiological factors such as patient age or food-intake. Reported as releasing drug independently of these factors, oral osmotically-driven systems (OODS) have taken an increasing place in the MR field. Using osmotic pressure as driving force, various OODS designs and compositions have been developed and launched...

Keywords

  • Push-pull osmotic systems
  • Asmotic pumps
  • Controlled release
  • Extended release
  • Low soluble drug

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

MALATERRE, Vincent. Strategies to design push-pull osmotic systems for delivering low and pH-dependent soluble drugs. Doctoral Thesis, 2009. doi: 10.13097/archive-ouverte/unige:2499

Main files (1)

Thesis

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Technical informations

Creation

21/08/2009 13:33:00

First validation

21/08/2009 13:33:00

Update

14/03/2023 15:10:49

Status update

14/03/2023 15:10:49

Last indexation

13/05/2025 15:38:53
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