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Thérapies ciblées en oncologie digestive

Published in Revue médicale suisse. 2011, vol. 7, no. 296, p. 1131-2,1134-6
Abstract Targeted therapies are relatively new molecules available for the oncologist. These drugs target a specific step of the cellular development and interfere with the intracellular signalization pathways. Amongst all others, EGF- and VEGF-pathways are currently targeted by these selective therapies. Modulating EGF and VEGF significantly improves overall survival and progression-free survival for many advanced or metastatic tumors as colorectal cancer, gastric cancer, gastrointestinal stromal tumors or hepatocellular carcinoma. Targeted therapies have a specific action site, a simple administration mode and are relatively well tolerated. In the future these molecules will probably be used "à la carte" for tumors that appear to be refractory to other drugs.
Keywords Angiogenesis Inhibitors/therapeutic useAntineoplastic Agents/therapeutic useCarcinoma, Hepatocellular/drug therapyColorectal Neoplasms/drug therapyDigestive System Neoplasms/drug therapyGastrointestinal Stromal Tumors/drug therapyHumansLiver Neoplasms/drug therapyMolecular Targeted TherapyReceptor, Epidermal Growth Factor/antagonists & inhibitorsReceptors, Vascular Endothelial Growth Factor/antagonists & inhibitorsSignal Transduction/drug effectsStomach Neoplasms/drug therapySurvival AnalysisTreatment Outcome
PMID: 21721202
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Other version: http://rms.medhyg.ch/
Research group Groupe Roth Arnaud (oncologie) (285)
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AMRAM, Marie-Laure, BENAMRAN, Daniel Alexandre Israel, ROTH, Arnaud. Thérapies ciblées en oncologie digestive. In: Revue médicale suisse, 2011, vol. 7, n° 296, p. 1131-2,1134-6. https://archive-ouverte.unige.ch/unige:24977

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Deposited on : 2013-01-04

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