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Title

The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice

Authors
McCall, Michael
Emamaullee, Juliet
Pawlick, Rena
Edgar, Ryan
Davis, Joy
Maciver, Allison
Kin, Tatsuya
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Published in Surgery. 2011, vol. 150, no. 1, p. 48-55
Abstract Islet transplantation has become a viable option for selected type 1 diabetic patients; however, a significant portion need to return to exogenous insulin. The predominant factors include impaired islet engraftment and early islet loss. Caspase inhibition is a potent way to improve islet engraftment, but all tested compounds so far have not been clinically relevant. IDN-6556 (PF3491390) has already been used clinically and can be delivered orally with high portal vein concentrations.
Keywords AnimalsApoptosis/drug effectsBlood Glucose/metabolismCaspases/antagonists & inhibitorsCysteine Proteinase Inhibitors/pharmacologyDiabetes Mellitus, Experimental/blood/drug therapy/surgeryGlucose Tolerance TestGraft Enhancement, Immunologic/methodsGraft Survival/drug effectsHumansIslets of Langerhans Transplantation/pathology/physiologyMiceMice, Inbred BALB CMice, KnockoutPentanoic Acids/pharmacologyTransplantation, HeterologousTransplantation, Isogeneic
Identifiers
PMID: 21596412
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Article (Published version) (342 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Transplantation et hépatologie (905)
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MCCALL, Michael et al. The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice. In: Surgery, 2011, vol. 150, n° 1, p. 48-55. https://archive-ouverte.unige.ch/unige:24964

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Deposited on : 2013-01-04

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