We evaluated the relationship between cup diameter and dislocation risk in patients undergoing primary total hip arthroplasty (THA) with a 28-mm head. There were 50 dislocations, 28 of which occurred in 2221 (1.3%) THAs with a cup diameter smaller than 56 mm and 22 in 513 (4.3%) with a cup diameter of 56 mm or larger. Dislocation risk varied between 0.6% and 2.4% in the smaller cup group and between 4.1% and 5.2% in the larger cup group. The risk was substantially higher in the large cup group (unadjusted odds ratio, 3.5; 95% confidence interval, 2.0-6.2). Multivariable logistic regression revealed an adjusted odds ratio of 2.4 (95% confidence interval, 1.2-4.9). Patients with THA (28-mm head) had more than twice the risk of dislocation with cup size of 56 mm or higher compared to patients with smaller cups.