In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification

Nasir-ud-Din; Ahmad, Ishtiaq; Khan, Tehmina S.; Hoessli, Daniel; Walker-Nasir, Evelyne; Kaleem, Afshan; Shakoori, Abdul R.

doi:10.2174/092986608783489607

Scientific article

English

In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification

ContributorsNasir-ud-Din; Ahmad, Ishtiaq; Khan, Tehmina S.; Hoessli, Daniel; Walker-Nasir, Evelyne; Kaleem, Afshan; Shakoori, Abdul R.

Published inProtein and peptide letters, vol. 15, no. 2, p. 193-199

Publication date2008

Abstract

Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplasm and back to nucleus, consequently modulating gene expression.

Keywords

Acetylglucosamine/chemistry/metabolism
Active Transport, Cell Nucleus/physiology
Amino Acid Sequence
Animals
Cell Nucleus/metabolism
Computer Simulation
Cytoplasm/metabolism
Gene Expression Regulation
HMGN1 Protein/chemistry/genetics/metabolism
Histones/metabolism
Humans
Molecular Sequence Data
Nucleosomes/metabolism
Phosphorylation
Protein Binding
Protein Processing, Post-Translational
Sequence Alignment

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Citation (ISO format)

NASIR-UD-DIN et al. In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification. In: Protein and peptide letters, 2008, vol. 15, n° 2, p. 193–199. doi: 10.2174/092986608783489607

Identifiers

PID : unige:2492
DOI : 10.2174/092986608783489607
PMID : 18289110

Commercial URLhttp://www.benthamdirect.org/pages/content.php?PPL/2008/00000015/00000002/0008E.SGM

ISSN of the journal0929-8665

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In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification

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