Scientific article
English

In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification

Published inProtein and peptide letters, vol. 15, no. 2, p. 193-199
Publication date2008
Abstract

Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplasm and back to nucleus, consequently modulating gene expression.

Keywords
  • Acetylglucosamine/chemistry/metabolism
  • Active Transport, Cell Nucleus/physiology
  • Amino Acid Sequence
  • Animals
  • Cell Nucleus/metabolism
  • Computer Simulation
  • Cytoplasm/metabolism
  • Gene Expression Regulation
  • HMGN1 Protein/chemistry/genetics/metabolism
  • Histones/metabolism
  • Humans
  • Molecular Sequence Data
  • Nucleosomes/metabolism
  • Phosphorylation
  • Protein Binding
  • Protein Processing, Post-Translational
  • Sequence Alignment
Citation (ISO format)
NASIR-UD-DIN et al. In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification. In: Protein and peptide letters, 2008, vol. 15, n° 2, p. 193–199. doi: 10.2174/092986608783489607
Identifiers
Journal ISSN0929-8665
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Update14/03/2023 15:10:47
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