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Title

In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification

Authors
Nasir-ud-Din,
Ahmad, Ishtiaq
Khan, Tehmina S.
Walker-Nasir, Evelyne
Kaleem, Afshan
Shakoori, Abdul R.
Published in Protein and Peptide Letters. 2008, vol. 15, no. 2, p. 193-9
Abstract Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplasm and back to nucleus, consequently modulating gene expression.
Keywords Acetylglucosamine/chemistry/metabolismActive Transport, Cell Nucleus/physiologyAmino Acid SequenceAnimalsCell Nucleus/metabolismComputer SimulationCytoplasm/metabolismGene Expression RegulationHMGN1 Protein/chemistry/genetics/metabolismHistones/metabolismHumansMolecular Sequence DataNucleosomes/metabolismPhosphorylationProtein BindingProtein Processing, Post-TranslationalSequence Alignment
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PMID: 18289110
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NASIR-UD-DIN et al. In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification. In: Protein and Peptide Letters, 2008, vol. 15, n° 2, p. 193-9. https://archive-ouverte.unige.ch/unige:2492

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Deposited on : 2009-08-25

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