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Title

Tri-layered electrospinning to mimic native arterial architecture using polycaprolactone, elastin, and collagen: a preliminary study

Authors
McClure, Michael J
Sell, Scott A
Simpson, David G
Bowlin, Gary L
Published in Journal of Visualized Experiments. 2011, no. 47
Abstract Throughout native artery, collagen and elastin play an important role, providing a mechanical backbone, preventing vessel rupture, and promoting recovery under pulsatile deformations. The goal of this study was to mimic the structure of native artery by fabricating a multi-layered electrospun conduit composed of poly(caprolactone) (PCL) with the addition of elastin and collagen with blends of 45-45-10, 55-35-10, and 65-25-10 PCL-ELAS-COL to demonstrate mechanical properties indicative of native arterial tissue, while remaining conducive to tissue regeneration. Whole grafts and individual layers were analyzed using uniaxial tensile testing, dynamic compliance, suture retention, and burst strength. Compliance results revealed that changes to the middle/medial layer changed overall graft behavior with whole graft compliance values ranging from 0.8 - 2.8 % / 100 mmHg, while uniaxial results demonstrated an average modulus range of 2.0 - 11.8 MPa. Both modulus and compliance data displayed values within the range of native artery. Mathematical modeling was implemented to show how changes in layer stiffness affect the overall circumferential wall stress, and as a design aid to achieve the best mechanical combination of materials. Overall, the results indicated that a graft can be designed to mimic a tri-layered structure by altering layer properties.
Keywords AnimalsBiomimetic Materials/chemistryBlood Vessel ProsthesisCattleCollagen/chemistryElastin/chemistryElectrochemical Techniques/methodsModels, BiologicalPolyesters/chemistry
Identifiers
PMID: 21248694
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Structures
Research group Chirurgie cardio-vasculaire (105)
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(ISO format)
MCCLURE, Michael J et al. Tri-layered electrospinning to mimic native arterial architecture using polycaprolactone, elastin, and collagen: a preliminary study. In: Journal of Visualized Experiments, 2011, n° 47. https://archive-ouverte.unige.ch/unige:24901

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Deposited on : 2013-01-03

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