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Survival in patients with uveal melanoma in Europe

Virgili, Gianni
Gatta, Gemma
Ciccolallo, Laura
Capocaccia, Riccardo
Biggeri, Annibale
Crocetti, Emanuele
Paci, Eugenio
Published in Archives of Ophthalmology. 2008, vol. 126, no. 10, p. 1413-8
Abstract OBJECTIVE: To estimate survival in patients in whom uveal melanoma was diagnosed between January 1, 1983, and December 31, 1994, in Europe. METHODS: Survival analysis of data from 32 cancer registries in 16 European countries adhering to the European Cancer Registry for 5788 patients with uveal melanoma diagnosed between January 1, 1983, and December 31, 1994, with follow-up to 1999. RESULTS: Five-year relative survival was 68.9% overall and remained stable with the period of diagnosis. Relative excess risk of death was 2.45 (95% confidence interval [CI], 2.10-2.86) in patients aged 75 years or older compared with patients aged 54 years or younger and was slightly higher in male patients (relative excess risk, 1.10; 95% CI, 1.02-1.19) than in female patients. Survival was similar in Nordic countries (relative excess risk, 1.03; 95% CI, 0.87-1.21) compared with the United Kingdom (reference country) and was lower in eastern and western European countries (1.26; 1.05-1.52, and 1.25; 0.90-1.60, respectively) compared with the reference country. CONCLUSIONS: In this large series of patients with uveal melanoma, 5-year relative survival remained stable with the introduction of conservative treatment in individuals in whom uveal melanoma was diagnosed between 1983 and 1994. We found differences in survival between sexes and in European areas that should be investigated in studies that consider tumor characteristics at the individual level.
Keywords AdolescentAdultAge DistributionAgedAged, 80 and overAnalysis of VarianceCause of DeathCohort StudiesDisease-Free SurvivalEurope/epidemiologyFemaleHumansIncidenceInternational Classification of DiseasesMaleMelanoma/diagnosis/mortality/therapyMiddle AgedMultivariate AnalysisProbabilityPrognosisRegistriesRetrospective StudiesRisk AssessmentSex DistributionSurvival AnalysisUveal Neoplasms/diagnosis/mortality/therapy
PMID: 18852420
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Research groups Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
EUROCARE Working Group
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VIRGILI, Gianni et al. Survival in patients with uveal melanoma in Europe. In: Archives of Ophthalmology, 2008, vol. 126, n° 10, p. 1413-8. doi: 10.1001/archopht.126.10.1413 https://archive-ouverte.unige.ch/unige:2483

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Deposited on : 2009-08-24

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