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Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour

Terris, Benoît
Rouquette, Alexandre
Audebourg, Anne
Dousset, Bertrand
Published in Digestive and Liver Disease. 2011, vol. 43, no. 12, p. 971-4
Abstract BACKGROUND: Acinar cell carcinomas of the pancreas are rare neoplasms. Usually diagnosed at an advanced stage, in general they are large solid pancreatic tumours with an average size of more than 10 cm. AIMS AND RESULTS: We report 3 cases of acinar cell carcinomas involving the peripancreatic lymph nodes, the liver hilum and the colon respectively, without clinical or pathological evidence of pancreatic tumours. These highly cellular neoplasms showed a predominantly acinar cell differentiation intermingled with a ductal component, with intracellular or extracellular mucin production by at least 25% of tumour cells. In addition, one case showed endocrine differentiation. Diffuse immunoreactivity for acinar enzymes trypsin and chymotrypsin was present in all cases. CONCLUSION: The occurrence of acinar cell carcinomas outside the pancreas underlines the notion that acinar cell carcinomas may originate in extrapancreatic sites and probably develop from heterotopic or metaplastic pancreatic foci present along the biliary tract.
Keywords AgedCarcinoma, Acinar Cell/diagnosis/pathology/secondary/surgeryChymotrypsin/analysisHumansImmunohistochemistryLiver Neoplasms/secondaryLymphatic MetastasisMaleMiddle AgedPancreatic Neoplasms/diagnosis/pathology/surgeryRetroperitoneal Neoplasms/secondaryTrypsin/analysis
PMID: 21893434
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Research groups Hépatologie chirurgicale (327)
Métastases du foie (657)
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TERRIS, Benoît et al. Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour. In: Digestive and Liver Disease, 2011, vol. 43, n° 12, p. 971-4. doi: 10.1016/j.dld.2011.07.013 https://archive-ouverte.unige.ch/unige:24810

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Deposited on : 2012-12-20

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