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Scientific article
Case report
English

Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour

Contributors

Terris, Benoît; Genevay-Infante, Muriel; Rouquette, Alexandre; Audebourg, Anne; Mentha, Gilles; Dousset, Bertrand; Rubbia-Brandt, Laura

Published in

Digestive and Liver Disease, vol. 43, no. 12, p. 971-974

Publication date

2011

Abstract

BACKGROUND: Acinar cell carcinomas of the pancreas are rare neoplasms. Usually diagnosed at an advanced stage, in general they are large solid pancreatic tumours with an average size of more than 10 cm. AIMS AND RESULTS: We report 3 cases of acinar cell carcinomas involving the peripancreatic lymph nodes, the liver hilum and the colon respectively, without clinical or pathological evidence of pancreatic tumours. These highly cellular neoplasms showed a predominantly acinar cell differentiation intermingled with a ductal component, with intracellular or extracellular mucin production by at least 25% of tumour cells. In addition, one case showed endocrine differentiation. Diffuse immunoreactivity for acinar enzymes trypsin and chymotrypsin was present in all cases. CONCLUSION: The occurrence of acinar cell carcinomas outside the pancreas underlines the notion that acinar cell carcinomas may originate in extrapancreatic sites and probably develop from heterotopic or metaplastic pancreatic foci present along the biliary tract.

Keywords

  • Aged
  • Carcinoma, Acinar Cell/diagnosis/pathology/secondary/surgery
  • Chymotrypsin/analysis
  • Humans
  • Immunohistochemistry
  • Liver Neoplasms/secondary
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Pancreatic Neoplasms/diagnosis/pathology/surgery
  • Retroperitoneal Neoplasms/secondary
  • Trypsin/analysis

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

TERRIS, Benoît et al. Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour. In: Digestive and Liver Disease, 2011, vol. 43, n° 12, p. 971–974. doi: 10.1016/j.dld.2011.07.013

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1590-8658
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Technical informations

Creation

10/12/2012 16:07:00

First validation

10/12/2012 16:07:00

Update

14/03/2023 17:48:22

Status update

14/03/2023 17:48:22

Last indexation

30/10/2024 08:08:09
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