Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients

Vallotton, Laure; Hadaya, Karine; Venetz, Jean-Pierre; Buehler, Leo Hans; Ciuffreda, Donatella; Nseir, Ghaleb; Codarri, Laura; Villard, Jean; Pantaleo, Giuseppe; Pascual, Manuel Antonio

doi:10.2215/CJN.09611010

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Title		Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients
Authors		Vallotton, Laure Hadaya, Karine Venetz, Jean-Pierre Buehler, Leo Hans Ciuffreda, Donatella Nseir, Ghaleb Codarri, Laura Villard, Jean Pantaleo, Giuseppe Pascual, Manuel Antonio show all authors [1 - 10]
Published in		Clinical Journal of the American Society of Nephrology. 2011, vol. 6, no. 8, p. 2025-33
Abstract		In humans, circulating CD4(+)CD25(high) T cells contain mainly regulatory T cells (Treg; FoxP3(+)IL-7Rα(low)), but a small subset is represented by activated effector T cells (Tact; FoxP3(-)IL-7Rα(high)). The balance between Tact and Treg may be important after transplantation. The aim of this study was first to analyze and correlate CD4(+)CD25(high) Tact and Treg with the clinical status of kidney transplant recipients and second to study prospectively the effect of two immunosuppressive regimens on Tact/Treg during the first year after transplantation.
Keywords		Adolescent — Adult — Aged — Biological Markers/blood — CD4-Positive T-Lymphocytes/drug effects/immunology — Child — Child, Preschool — Drug Therapy, Combination — Female — Flow Cytometry — Graft Rejection/immunology/prevention & control — Graft Survival — Humans — Immunity, Cellular — Immunity, Humoral — Immunophenotyping — Immunosuppressive Agents/therapeutic use — Interleukin-2 Receptor alpha Subunit/blood — Kidney Transplantation/immunology — Lymphocyte Activation/drug effects — Lymphocyte Count — Male — Middle Aged — Monitoring, Immunologic/methods — Prospective Studies — Receptors, Interleukin-7/blood — Retrospective Studies — Switzerland — T-Lymphocytes, Regulatory/immunology — Time Factors — Treatment Outcome — Young Adult
Identifiers		DOI: 10.2215/CJN.09611010 PMID: 21757642
Full text		Article (Published version) (671 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups		Hépatologie chirurgicale (327) Cultures cellulaires et transplantations (519) Transplantation Immunologie et Osteoimmunologie (561)
Citation (ISO format)		VALLOTTON, Laure et al. Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients. In: Clinical Journal of the American Society of Nephrology, 2011, vol. 6, n° 8, p. 2025-33. doi: 10.2215/CJN.09611010 https://archive-ouverte.unige.ch/unige:24801