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Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients

Vallotton, Laure
Venetz, Jean-Pierre
Nseir, Ghaleb
Codarri, Laura
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Published in Clinical journal of the American Society of Nephrology. 2011, vol. 6, no. 8, p. 2025-33
Abstract In humans, circulating CD4(+)CD25(high) T cells contain mainly regulatory T cells (Treg; FoxP3(+)IL-7Rα(low)), but a small subset is represented by activated effector T cells (Tact; FoxP3(-)IL-7Rα(high)). The balance between Tact and Treg may be important after transplantation. The aim of this study was first to analyze and correlate CD4(+)CD25(high) Tact and Treg with the clinical status of kidney transplant recipients and second to study prospectively the effect of two immunosuppressive regimens on Tact/Treg during the first year after transplantation.
Keywords AdolescentAdultAgedBiological Markers/bloodCD4-Positive T-Lymphocytes/drug effects/immunologyChildChild, PreschoolDrug Therapy, CombinationFemaleFlow CytometryGraft Rejection/immunology/prevention & controlGraft SurvivalHumansImmunity, CellularImmunity, HumoralImmunophenotypingImmunosuppressive Agents/therapeutic useInterleukin-2 Receptor alpha Subunit/bloodKidney Transplantation/immunologyLymphocyte Activation/drug effectsLymphocyte CountMaleMiddle AgedMonitoring, Immunologic/methodsProspective StudiesReceptors, Interleukin-7/bloodRetrospective StudiesSwitzerlandT-Lymphocytes, Regulatory/immunologyTime FactorsTreatment OutcomeYoung Adult
PMID: 21757642
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Article (Published version) (671 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Cultures cellulaires et transplantations (519)
Hépatologie chirurgicale (327)
Transplantation Immunologie et Osteoimmunologie (561)
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VALLOTTON, Laure et al. Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients. In: Clinical journal of the American Society of Nephrology, 2011, vol. 6, n° 8, p. 2025-33. doi: 10.2215/CJN.09611010 https://archive-ouverte.unige.ch/unige:24801

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Deposited on : 2012-12-20

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