Scientific article

Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients

Published inClinical journal of the American Society of Nephrology, vol. 6, no. 8, p. 2025-2033
Publication date2011

In humans, circulating CD4(+)CD25(high) T cells contain mainly regulatory T cells (Treg; FoxP3(+)IL-7Rα(low)), but a small subset is represented by activated effector T cells (Tact; FoxP3(-)IL-7Rα(high)). The balance between Tact and Treg may be important after transplantation. The aim of this study was first to analyze and correlate CD4(+)CD25(high) Tact and Treg with the clinical status of kidney transplant recipients and second to study prospectively the effect of two immunosuppressive regimens on Tact/Treg during the first year after transplantation.

  • Adolescent
  • Adult
  • Aged
  • Biological Markers/blood
  • CD4-Positive T-Lymphocytes/drug effects/immunology
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • Female
  • Flow Cytometry
  • Graft Rejection/immunology/prevention & control
  • Graft Survival
  • Humans
  • Immunity, Cellular
  • Immunity, Humoral
  • Immunophenotyping
  • Immunosuppressive Agents/therapeutic use
  • Interleukin-2 Receptor alpha Subunit/blood
  • Kidney Transplantation/immunology
  • Lymphocyte Activation/drug effects
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Monitoring, Immunologic/methods
  • Prospective Studies
  • Receptors, Interleukin-7/blood
  • Retrospective Studies
  • Switzerland
  • T-Lymphocytes, Regulatory/immunology
  • Time Factors
  • Treatment Outcome
  • Young Adult
Citation (ISO format)
VALLOTTON, Laure et al. Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients. In: Clinical journal of the American Society of Nephrology, 2011, vol. 6, n° 8, p. 2025–2033. doi: 10.2215/CJN.09611010
Main files (1)
Article (Published version)
ISSN of the journal1555-9041

Technical informations

Creation12/17/2012 3:56:00 PM
First validation12/17/2012 3:56:00 PM
Update time03/14/2023 5:48:19 PM
Status update03/14/2023 5:48:19 PM
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