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Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients |
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Published in | Clinical journal of the American Society of Nephrology. 2011, vol. 6, no. 8, p. 2025-33 | |
Abstract | In humans, circulating CD4(+)CD25(high) T cells contain mainly regulatory T cells (Treg; FoxP3(+)IL-7Rα(low)), but a small subset is represented by activated effector T cells (Tact; FoxP3(-)IL-7Rα(high)). The balance between Tact and Treg may be important after transplantation. The aim of this study was first to analyze and correlate CD4(+)CD25(high) Tact and Treg with the clinical status of kidney transplant recipients and second to study prospectively the effect of two immunosuppressive regimens on Tact/Treg during the first year after transplantation. | |
Keywords | Adolescent — Adult — Aged — Biological Markers/blood — CD4-Positive T-Lymphocytes/drug effects/immunology — Child — Child, Preschool — Drug Therapy, Combination — Female — Flow Cytometry — Graft Rejection/immunology/prevention & control — Graft Survival — Humans — Immunity, Cellular — Immunity, Humoral — Immunophenotyping — Immunosuppressive Agents/therapeutic use — Interleukin-2 Receptor alpha Subunit/blood — Kidney Transplantation/immunology — Lymphocyte Activation/drug effects — Lymphocyte Count — Male — Middle Aged — Monitoring, Immunologic/methods — Prospective Studies — Receptors, Interleukin-7/blood — Retrospective Studies — Switzerland — T-Lymphocytes, Regulatory/immunology — Time Factors — Treatment Outcome — Young Adult | |
Identifiers | DOI: 10.2215/CJN.09611010 PMID: 21757642 | |
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Research groups | Cultures cellulaires et transplantations (519) Hépatologie chirurgicale (327) Transplantation Immunologie et Osteoimmunologie (561) | |
Citation (ISO format) | VALLOTTON, Laure et al. Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients. In: Clinical journal of the American Society of Nephrology, 2011, vol. 6, n° 8, p. 2025-33. doi: 10.2215/CJN.09611010 https://archive-ouverte.unige.ch/unige:24801 |