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Title

Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients

Authors
Vallotton, Laure
Venetz, Jean-Pierre
Nseir, Ghaleb
Codarri, Laura
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Published in Clinical Journal of the American Society of Nephrology. 2011, vol. 6, no. 8, p. 2025-33
Abstract In humans, circulating CD4(+)CD25(high) T cells contain mainly regulatory T cells (Treg; FoxP3(+)IL-7Rα(low)), but a small subset is represented by activated effector T cells (Tact; FoxP3(-)IL-7Rα(high)). The balance between Tact and Treg may be important after transplantation. The aim of this study was first to analyze and correlate CD4(+)CD25(high) Tact and Treg with the clinical status of kidney transplant recipients and second to study prospectively the effect of two immunosuppressive regimens on Tact/Treg during the first year after transplantation.
Keywords AdolescentAdultAgedBiological Markers/bloodCD4-Positive T-Lymphocytes/drug effects/immunologyChildChild, PreschoolDrug Therapy, CombinationFemaleFlow CytometryGraft Rejection/immunology/prevention & controlGraft SurvivalHumansImmunity, CellularImmunity, HumoralImmunophenotypingImmunosuppressive Agents/therapeutic useInterleukin-2 Receptor alpha Subunit/bloodKidney Transplantation/immunologyLymphocyte Activation/drug effectsLymphocyte CountMaleMiddle AgedMonitoring, Immunologic/methodsProspective StudiesReceptors, Interleukin-7/bloodRetrospective StudiesSwitzerlandT-Lymphocytes, Regulatory/immunologyTime FactorsTreatment OutcomeYoung Adult
Identifiers
PMID: 21757642
Full text
Article (Published version) (671 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Hépatologie chirurgicale (327)
Cultures cellulaires et transplantations (519)
Transplantation Immunologie et Osteoimmunologie (561)
Citation
(ISO format)
VALLOTTON, Laure et al. Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients. In: Clinical Journal of the American Society of Nephrology, 2011, vol. 6, n° 8, p. 2025-33. https://archive-ouverte.unige.ch/unige:24801

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Deposited on : 2012-12-20

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