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Title

Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells

Authors
Golshayan, Déla
Wyss, Jean Christophe
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Published in Diabetes. 2011, vol. 60, no. 9, p. 2331-40
Abstract Streptozotocin (STZ) is the most widely used diabetogenic agent in animal models of islet transplantation. However, the immunomodifying effects of STZ and the ensuing hyperglycemia on lymphocyte subsets, particularly on T regulatory cells (Tregs), remain poorly understood.
Keywords Adaptive Immunity/immunologyAnimalsCell ProliferationDiabetes Mellitus, Experimental/complications/immunologyImmune Tolerance/immunologyLymphopenia/etiology/immunologyMiceRatsSpleen/immunologyStreptozocinT-Lymphocytes, Regulatory/immunology
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PMID: 21752956
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Article (Published version) (1.8 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
Cultures cellulaires et transplantations (519)
Chirurgie viscérale (104)
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(ISO format)
MULLER, Yannick et al. Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells. In: Diabetes, 2011, vol. 60, n° 9, p. 2331-40. https://archive-ouverte.unige.ch/unige:24800

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Deposited on : 2012-12-20

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