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Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells |
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Published in | Diabetes. 2011, vol. 60, no. 9, p. 2331-40 | |
Abstract | Streptozotocin (STZ) is the most widely used diabetogenic agent in animal models of islet transplantation. However, the immunomodifying effects of STZ and the ensuing hyperglycemia on lymphocyte subsets, particularly on T regulatory cells (Tregs), remain poorly understood. | |
Keywords | Adaptive Immunity/immunology — Animals — Cell Proliferation — Diabetes Mellitus, Experimental/complications/immunology — Immune Tolerance/immunology — Lymphopenia/etiology/immunology — Mice — Rats — Spleen/immunology — Streptozocin — T-Lymphocytes, Regulatory/immunology | |
Identifiers | DOI: 10.2337/db11-0159 PMID: 21752956 | |
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Research groups | Chirurgie viscérale (104) Chirurgie viscérale (HUG) Cultures cellulaires et transplantations (519) Laboratoire d'immunologie translationnelle (856) | |
Citation (ISO format) | MULLER, Yannick et al. Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells. In: Diabetes, 2011, vol. 60, n° 9, p. 2331-40. doi: 10.2337/db11-0159 https://archive-ouverte.unige.ch/unige:24800 |