Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells

Muller, Yannick; Golshayan, Déla; Ehirchiou, Driss; Wyss, Jean Christophe; Giovannoni, Laurianne; Meier, Raphaël; Serre Beinier, Véronique; Puga Yung, Gisella; Morel, Philippe; Buehler, Leo Hans; Seebach, Jorg Dieter

doi:10.2337/db11-0159

Scientific article

English

Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells

ContributorsMuller, Yannick; Golshayan, Déla; Ehirchiou, Driss; Wyss, Jean Christophe; Giovannoni, Laurianne; Meier, Raphaël; Serre Beinier, Véronique

; Puga Yung, Gisella

; Morel, Philippe; Buehler, Leo Hans; Seebach, Jorg Dieter

Published inDiabetes, vol. 60, no. 9, p. 2331-2340

Publication date2011

Abstract

Streptozotocin (STZ) is the most widely used diabetogenic agent in animal models of islet transplantation. However, the immunomodifying effects of STZ and the ensuing hyperglycemia on lymphocyte subsets, particularly on T regulatory cells (Tregs), remain poorly understood.

Keywords

Adaptive Immunity/immunology
Animals
Cell Proliferation
Diabetes Mellitus, Experimental/complications/immunology
Immune Tolerance/immunology
Lymphopenia/etiology/immunology
Mice
Rats
Spleen/immunology
Streptozocin
T-Lymphocytes, Regulatory/immunology

Affiliation entities

Research groups

Citation (ISO format)

MULLER, Yannick et al. Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells. In: Diabetes, 2011, vol. 60, n° 9, p. 2331–2340. doi: 10.2337/db11-0159

Article (Published version)

Identifiers

PID : unige:24800
DOI : 10.2337/db11-0159
PMID : 21752956

Journal ISSN0012-1797

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Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells

Streptozotocin (STZ) is the most widely used diabetogenic agent in animal models of islet transplantation. However, the immunomodifying effects of STZ and the ensuing hyperglycemia on lymphocyte subsets, particularly on T regulatory cells (Tregs), remain poorly understood.

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