Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells

Muller, Yannick; Golshayan, Déla; Ehirchiou, Driss; Wyss, Jean Christophe; Giovannoni, Laurianne; Meier, Raphaël; Serre Beinier, Véronique; Puga Yung, Gisella; Morel, Philippe; Buehler, Leo Hans; Seebach, Jorg Dieter

doi:10.2337/db11-0159

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Title		Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells
Authors		Muller, Yannick Golshayan, Déla Ehirchiou, Driss Wyss, Jean Christophe Giovannoni, Laurianne Meier, Raphaël Serre Beinier, Véronique Puga Yung, Gisella Morel, Philippe Buehler, Leo Hans Seebach, Jorg Dieter show all authors [1 - 11]
Published in		Diabetes. 2011, vol. 60, no. 9, p. 2331-40
Abstract		Streptozotocin (STZ) is the most widely used diabetogenic agent in animal models of islet transplantation. However, the immunomodifying effects of STZ and the ensuing hyperglycemia on lymphocyte subsets, particularly on T regulatory cells (Tregs), remain poorly understood.
Keywords		Adaptive Immunity/immunology — Animals — Cell Proliferation — Diabetes Mellitus, Experimental/complications/immunology — Immune Tolerance/immunology — Lymphopenia/etiology/immunology — Mice — Rats — Spleen/immunology — Streptozocin — T-Lymphocytes, Regulatory/immunology
Identifiers		DOI: 10.2337/db11-0159 PMID: 21752956
Full text		Article (Published version) (1.8 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups		Chirurgie viscérale (104) Chirurgie viscérale (HUG) Cultures cellulaires et transplantations (519) Laboratoire d'immunologie translationnelle (856)
Citation (ISO format)		MULLER, Yannick et al. Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells. In: Diabetes, 2011, vol. 60, n° 9, p. 2331-40. doi: 10.2337/db11-0159 https://archive-ouverte.unige.ch/unige:24800