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The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo |
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Published in | Nature immunology. 2011, vol. 12, no. 8, p. 761-9 | |
Abstract | The migration of neutrophils into inflamed tissues is a fundamental component of innate immunity. A decisive step in this process is the polarized migration of blood neutrophils through endothelial cells (ECs) lining the venular lumen (transendothelial migration (TEM)) in a luminal-to-abluminal direction. By real-time confocal imaging, we found that neutrophils had disrupted polarized TEM ('hesitant' and 'reverse') in vivo. We noted these events in inflammation after ischemia-reperfusion injury, characterized by lower expression of junctional adhesion molecule C (JAM-C) at EC junctions, and they were enhanced by blockade or genetic deletion of JAM-C in ECs. Our results identify JAM-C as a key regulator of polarized neutrophil TEM in vivo and suggest that reverse TEM of neutrophils can contribute to the dissemination of systemic inflammation. | |
Keywords | Animals — Cell Adhesion Molecules/immunology — Endothelium, Vascular/cytology/immunology/pathology — Image Processing, Computer-Assisted — Immunoglobulins/immunology — Inflammation/immunology/pathology — Mice — Microscopy, Confocal — Neutrophils/immunology — Reperfusion Injury/immunology/pathology — Transendothelial and Transepithelial Migration/immunology | |
Identifiers | DOI: 10.1038/ni.2062 PMID: 21706006 | |
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Research groups | Couplage cellulaire et connexines (136) Molécules d'adhésion et processus de migration cellulaire (167) | |
Citation (ISO format) | WOODFIN, Abigail et al. The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. In: Nature immunology, 2011, vol. 12, n° 8, p. 761-9. doi: 10.1038/ni.2062 https://archive-ouverte.unige.ch/unige:24793 |