Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability

Montecucco, Fabrizio; Vuilleumier, Nicolas; Pagano, Sabrina; Lenglet, Sébastien; Bertolotto, Maria; Braunersreuther, Vincent; Pelli, Graziano; Kovari, Eniko Veronika; Pane, Bianca; Spinella, Giovanni; Pende, Aldo; Palombo, Domenico; Dallegri, Franco; Mach, François; Roux-Lombard, Pascale

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Title		Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability
Authors		Montecucco, Fabrizio Vuilleumier, Nicolas Pagano, Sabrina Lenglet, Sébastien Bertolotto, Maria Braunersreuther, Vincent Pelli, Graziano Kovari, Eniko Veronika Pane, Bianca Spinella, Giovanni Pende, Aldo Palombo, Domenico Dallegri, Franco Mach, François Roux-Lombard, Pascale show all authors [1 - 15]
Published in		European Heart Journal. 2011, vol. 32, no. 4, p. 412-21
Abstract		Anti-Apolipoprotein A-1 auto-antibodies (anti-ApoA-1 IgG) represent an emerging prognostic cardiovascular marker in patients with myocardial infarction or autoimmune diseases associated with high cardiovascular risk. The potential relationship between anti-ApoA-1 IgG and plaque vulnerability remains elusive. Thus, we aimed to investigate the role of anti-ApoA-1 IgG in plaque vulnerability.
Keywords		Aged — Animals — Apolipoprotein A-I/immunology — Autoantibodies/blood — Biological Markers/blood — Carotid Artery, Internal — Carotid Stenosis/immunology — Cohort Studies — Collagen/metabolism — Cytokines/metabolism — Enzyme-Linked Immunosorbent Assay — Female — Humans — Immunoglobulin G/blood — Male — Matrix Metalloproteinase 9/metabolism — Mice — Mice, Inbred C57BL — Plaque, Atherosclerotic/immunology
Identifiers		DOI: 10.1093/eurheartj/ehq521 PMID: 21224292
Full text		Article (Published version) (152 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research groups		Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779) Groupe Bouras Constantin (neuropsychiatrie) (1) L'athérosclérose et ses complications cliniques (591) Traits génétiques complexes (901) Chimie et protéomique clinique (270)
Citation (ISO format)		MONTECUCCO, Fabrizio et al. Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability. In: European Heart Journal, 2011, vol. 32, n° 4, p. 412-21. https://archive-ouverte.unige.ch/unige:24776