Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability

Montecucco, Fabrizio; Vuilleumier, Nicolas; Pagano, Sabrina; Lenglet, Sébastien; Bertolotto, Maria; Braunersreuther, Vincent; Pelli, Graziano; Kovari, Eniko Veronika; Pane, Bianca; Spinella, Giovanni; Pende, Aldo; Palombo, Domenico; Dallegri, Franco; Mach, François; Roux-Lombard, Pascale

doi:10.1093/eurheartj/ehq521

Scientific article

English

Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability

ContributorsMontecucco, Fabrizio; Vuilleumier, Nicolas; Pagano, Sabrina

; Lenglet, Sébastien; Bertolotto, Maria; Braunersreuther, Vincent; Pelli, Graziano; Kovari, Eniko Veronika; Pane, Bianca; Spinella, Giovanni; Pende, Aldo; Palombo, Domenico; Dallegri, Franco; Mach, François; Roux-Lombard, Pascale

Published inEuropean heart journal, vol. 32, no. 4, p. 412-421

Publication date2011

Abstract

Anti-Apolipoprotein A-1 auto-antibodies (anti-ApoA-1 IgG) represent an emerging prognostic cardiovascular marker in patients with myocardial infarction or autoimmune diseases associated with high cardiovascular risk. The potential relationship between anti-ApoA-1 IgG and plaque vulnerability remains elusive. Thus, we aimed to investigate the role of anti-ApoA-1 IgG in plaque vulnerability.

Keywords

Aged
Animals
Apolipoprotein A-I/immunology
Autoantibodies/blood
Biological Markers/blood
Carotid Artery, Internal
Carotid Stenosis/immunology
Cohort Studies
Collagen/metabolism
Cytokines/metabolism
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G/blood
Male
Matrix Metalloproteinase 9/metabolism
Mice
Mice, Inbred C57BL
Plaque, Atherosclerotic/immunology

Affiliation entities

Research groups

Citation (ISO format)

MONTECUCCO, Fabrizio et al. Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability. In: European heart journal, 2011, vol. 32, n° 4, p. 412–421. doi: 10.1093/eurheartj/ehq521

Article (Published version)

Identifiers

PID : unige:24776
DOI : 10.1093/eurheartj/ehq521
PMID : 21224292

Journal ISSN0195-668X

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Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability

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