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Title

Clinical validation of an automated vessel-segmentation software of the extracranial-carotid arteries based on 3D-MRA: a prospective study

Authors
Guzman, R.
Altrichter, S.
Remonda, L.
de Koning, P.
Andres, R.H.
El-Koussy, M.
Kelly, M.E.
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Published in Journal of Neuroradiology. 2008, vol. 35, no. 5, p. 278-85
Abstract OBJECTIVES: To determine the accuracy of automated vessel-segmentation software for vessel-diameter measurements based on three-dimensional contrast-enhanced magnetic resonance angiography (3D-MRA). METHOD: In 10 patients with high-grade carotid stenosis, automated measurements of both carotid arteries were obtained with 3D-MRA by two independent investigators and compared with manual measurements obtained by digital subtraction angiography (DSA) and 2D maximum-intensity projection (2D-MIP) based on MRA and duplex ultrasonography (US). In 42 patients undergoing carotid endarterectomy (CEA), intraoperative measurements (IOP) were compared with postoperative 3D-MRA and US. RESULTS: Mean interoperator variability was 8% for measurements by DSA and 11% by 2D-MIP, but there was no interoperator variability with the automated 3D-MRA analysis. Good correlations were found between DSA (standard of reference), manual 2D-MIP (rP=0.6) and automated 3D-MRA (rP=0.8). Excellent correlations were found between IOP, 3D-MRA (rP=0.93) and US (rP=0.83). CONCLUSION: Automated 3D-MRA-based vessel segmentation and quantification result in accurate measurements of extracerebral-vessel dimensions.
Keywords AgedAnalysis of VarianceAngiography, Digital SubtractionCarotid Stenosis/diagnosis/surgeryContrast MediaEndarterectomy, CarotidFemaleHumansImage Interpretation, Computer-Assisted/methodsImaging, Three-DimensionalMagnetic Resonance Angiography/methodsMaleProspective StudiesRetrospective StudiesSoftware ValidationStatistics, NonparametricTreatment OutcomeUltrasonography, Doppler, Duplex
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PMID: 18707758
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Research group Ischémie cérébrale et connectivité (801)
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GUZMAN, R. et al. Clinical validation of an automated vessel-segmentation software of the extracranial-carotid arteries based on 3D-MRA: a prospective study. In: Journal of Neuroradiology, 2008, vol. 35, n° 5, p. 278-85. https://archive-ouverte.unige.ch/unige:2467

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Deposited on : 2009-08-21

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