Tumor incidence in related hematopoietic stem cell donors

Jeger, A; Favre, G; Lutz, Jean-Michel; Stern, M; Usel, Massimo; Rovo, A; Rischewski, J; Tichelli, A; Gratwohl, Alois; Halter, J

doi:10.1038/bmt.2010.291

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Title		Tumor incidence in related hematopoietic stem cell donors
Authors		Jeger, A Favre, G Lutz, Jean-Michel Stern, M Usel, Massimo Rovo, A Rischewski, J Tichelli, A Gratwohl, Alois Halter, J show all authors [1 - 10]
Published in		Bone marrow transplantation. 2011, vol. 46, no. 9, p. 1240-4
Abstract		Late malignancies have been discussed as a potential risk for growth factor mobilized donors of hematopoietic stem cells. Little is known about the incidence and potential risk factors. This single center retrospective cohort study evaluated all HLA-identical sibling pairs with hematopoietic stem cell transplantation (HSCT) for a hematological malignancy, treated from 1974 to 2001 at the University Hospital of Basel. Three hundred eighteen pairs were identified, 291 donors (92%) could be contacted. Median observation time was 13.8 years (range 5-32 years). Sixteen (5%) donors had developed a total of 18 tumors, 17 recipients a secondary tumor. According to the age- and sex-adapted cancer incidence, 3.3 tumors in male and 6.8 in female donors were expected, 3 (relative risk (RR): 0.91, 95% confidence interval: 0.19-2.66) and 4 (RR: 0.58, 95% confidence interval: 0.16-1.48), respectively, were found in donors between 0 and 49 years. Between 50 and 69 years, 4.5 tumors in males and 4.8 in females were expected, 5 (RR: 1.11, 95% confidence interval: 0.36-2.59) and 6 (RR: 1.23, 95% confidence interval: 0.45-2.67), respectively, were observed. Tumors do occur in donors of hematopoietic stem cells at least at the rate as expected in a normal population; whether incidence exceeds expected rates needs to be determined in larger international cohorts.
Keywords		Adolescent — Adult — Aged — Aged, 80 and over — Child — Cohort Studies — Female — Germany/epidemiology — Hematopoietic Stem Cell Transplantation/statistics & numerical data — Humans — Incidence — Male — Middle Aged — Neoplasms/epidemiology — Retrospective Studies — Switzerland/epidemiology — Tissue Donors/statistics & numerical data — Young Adult
Identifiers		DOI: 10.1038/bmt.2010.291 PMID: 21170092
Full text		Article (Published version) (240 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de santé globale / Registre genevois des tumeurs
Research group		Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
Citation (ISO format)		JEGER, A et al. Tumor incidence in related hematopoietic stem cell donors. In: Bone marrow transplantation, 2011, vol. 46, n° 9, p. 1240-4. doi: 10.1038/bmt.2010.291 https://archive-ouverte.unige.ch/unige:24624