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Title

Total Synthesis of 16-Desmethylepothilone B, Epothilone B 10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues

Authors
Nicolaou, K. C.
Hepworth, David
King, N. Paul
Finlay, M. Raymond V.
Scarpelli, Rita
Pereira, M. Manuela A.
Bollbuck, Birgit
Bigot, Antony
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Published in Chemistry - A European Journal. 2000, vol. 6, no. 15, p. 2783-2800
Abstract The macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and improved to a high level of efficiency and stereoselectivity. This strategy has been applied to the construction of vinyl iodide 19 which served as a common intermediate for the synthesis of a series of natural and designed epothilones including an epothilone B10 (3), epothilone F (5), 16-desmethylepothilone B (14), pyridine epothilones 57 a–57 g, dimeric epothilones 59 and 61, and benzenoid epothilones 63 a–63 g.
Keywords antitumor agentsdesigned analoguesepothilonetotal synthesis
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NICOLAOU, K. C. et al. Total Synthesis of 16-Desmethylepothilone B, Epothilone B 10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues. In: Chemistry - A European Journal, 2000, vol. 6, n° 15, p. 2783-2800. https://archive-ouverte.unige.ch/unige:24509

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Deposited on : 2012-12-12

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