Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone

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Title		Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone
Authors		Nicolaou, K. C. Winssinger, Nicolas Pastor, Joaquin Murphy, Fiona
Published in		Angewandte Chemie: International Edition. 1998, vol. 37, no. 18, p. 2534-2537
Abstract		No heteroatom required! In many solid-phase syntheses, after the release from the polymer support a heteroatom (e.g. O, S, N) remains in the substrate as a residue of a linking protecting group. With polymer-bound tin reagents cleavage and cyclization of the substrate with C–C bond formation (see picture) can now be achieved by intramolecular Stille coupling. S=substrate.
Keywords		Cyclizations — Natural products — Solid-phase synthesis — Stille coupling — Synthetic methods
Identifiers		DOI: 10.1002/(SICI)1521-3773(19981002)37:18<2534::AID-ANIE2534>3.0.CO;2-F
Full text		Article (Published version) (193 Kb) - Limited access to UNIGE
Citation (ISO format)		NICOLAOU, K. C. et al. Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone. In: Angewandte Chemie: International Edition, 1998, vol. 37, n° 18, p. 2534-2537. doi: 10.1002/(SICI)1521-3773(19981002)37:18<2534::AID-ANIE2534>3.0.CO;2-F https://archive-ouverte.unige.ch/unige:24497

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