

Other version: http://doi.wiley.com/10.1002/%28SICI%291521-3773%2819981002%2937%3A18%3C2534%3A%3AAID-ANIE2534%3E3.0.CO%3B2-F
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Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone |
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Published in | Angewandte Chemie: International Edition. 1998, vol. 37, no. 18, p. 2534-2537 | |
Abstract | No heteroatom required! In many solid-phase syntheses, after the release from the polymer support a heteroatom (e.g. O, S, N) remains in the substrate as a residue of a linking protecting group. With polymer-bound tin reagents cleavage and cyclization of the substrate with C–C bond formation (see picture) can now be achieved by intramolecular Stille coupling. S=substrate. | |
Keywords | Cyclizations — Natural products — Solid-phase synthesis — Stille coupling — Synthetic methods | |
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![]() ![]() Other version: http://doi.wiley.com/10.1002/%28SICI%291521-3773%2819981002%2937%3A18%3C2534%3A%3AAID-ANIE2534%3E3.0.CO%3B2-F |
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Citation (ISO format) | NICOLAOU, K. C. et al. Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone. In: Angewandte Chemie: International Edition, 1998, vol. 37, n° 18, p. 2534-2537. https://archive-ouverte.unige.ch/unige:24497 |