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Title

Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone

Authors
Nicolaou, K. C.
Pastor, Joaquin
Murphy, Fiona
Published in Angewandte Chemie: International Edition. 1998, vol. 37, no. 18, p. 2534-2537
Abstract No heteroatom required! In many solid-phase syntheses, after the release from the polymer support a heteroatom (e.g. O, S, N) remains in the substrate as a residue of a linking protecting group. With polymer-bound tin reagents cleavage and cyclization of the substrate with C–C bond formation (see picture) can now be achieved by intramolecular Stille coupling. S=substrate.
Keywords CyclizationsNatural productsSolid-phase synthesisStille couplingSynthetic methods
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NICOLAOU, K. C. et al. Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone. In: Angewandte Chemie: International Edition, 1998, vol. 37, n° 18, p. 2534-2537. https://archive-ouverte.unige.ch/unige:24497

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Deposited on : 2012-12-12

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