High time-resolved cardiac functional imaging using temporal regularization for small animal on a clinical 3T scanner

Delattre, Bénédicte; Van De Ville, Dimitri; Braunersreuther, Vincent; Pellieux, Corinne; Hyacinthe, Jean-Noël; Lerch, René; Mach, François; Vallée, Jean-Paul

doi:10.1109/TBME.2011.2174363

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Title		High time-resolved cardiac functional imaging using temporal regularization for small animal on a clinical 3T scanner
Authors		Delattre, Bénédicte Van De Ville, Dimitri Braunersreuther, Vincent Pellieux, Corinne Hyacinthe, Jean-Noël Lerch, René Mach, François Vallée, Jean-Paul
Published in		IEEE transactions on biomedical engineering. 2012, vol. 59, no. 4, p. 929-35
Abstract		Accurate assessment of mice cardiac function with magnetic resonance imaging is essential for longitudinal studies and for drug development related to cardiovascular diseases. Whereas dedicated small animal MR scanners are not readily available, it would be a great advantage to be able to perform cardiac assessment on clinical systems, in particular, in the context of translational research. However, mouse imaging remains challenging since it requires both high spatial and temporal resolutions, while gradient performances of clinical scanners often limit the reachable parameters. In this study, we propose a new cine sequence, named "interleaved cine," which combines two repetitions of a standard cine sequence shifted in time in order to reach resolution parameters compatible with mice imaging. More precisely, this sequence allows temporal resolution to be reduced to 6.8 ms instead of 13.5 ms initially imposed by the system's hardware. We also propose a two-step denoising algorithm to suppress some artifacts inherent to the new interleaved cine thus allowing an efficient enhancement of the image quality. In particular, we model and suppress the periodic intensity pattern and further denoise the sequence by soft thresholding of the temporal Fourier coefficients. This sequence was successfully validated with mass and function measurements on relevant mice models of cardiovascular diseases.
Keywords		Algorithms — Animals — Hypertrophy, Left Ventricular/pathology/physiopathology — Image Enhancement/instrumentation/methods — Magnetic Resonance Imaging, Cine/instrumentation/methods/veterinary — Male — Mice — Mice, Inbred C57BL — Reproducibility of Results — Sensitivity and Specificity
Identifiers		DOI: 10.1109/TBME.2011.2174363 PMID: 22057042
Full text		Article (Published version) (819 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Biologie du myocarde (22) Imagerie cardiaque fonctionnelle (541) L'athérosclérose et ses complications cliniques (591) Traitement d'images médicales (893)
Citation (ISO format)		DELATTRE, Bénédicte et al. High time-resolved cardiac functional imaging using temporal regularization for small animal on a clinical 3T scanner. In: IEEE transactions on biomedical engineering, 2012, vol. 59, n° 4, p. 929-35. doi: 10.1109/TBME.2011.2174363 https://archive-ouverte.unige.ch/unige:24418