en
Scientific article
Review
Open access
English

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Published inJournal of drug delivery science and technology, vol. 22, no. 5, p. 393-408
Publication date2012
Abstract

Hyperthermia, an established adjuvant in cancer treatment, potentiates the effects of anticancer drugs and synergetic combination can be obtained improving the therapeutic outcome. Bone metastases may benefit from this combination when treated through in situ forming implants. Once loaded with magnetizable (nano-) particles and antineoplastic agents, these implants allow for the local application of magnetically-induced hyperthermia and the release of an anticancer drug. The implant can be heated applying an external magnetic field, sensitizing the surrounding tumoral tissues, while releasing the chemotherapeutic agent. Moreover, bone implants provide mechanical support to the weakened bone and consequently relieve pain. This review gives an overview of the current knowledge as well as the rationale of combining locally both magnetic hyperthermia and chemotherapy using in situ forming implants in the field of bone metastases treatment.

Keywords
  • Induced hyperthermia
  • Chemotherapy
  • Drug delivery systems
  • In situ forming implants
  • Iron oxide nanoparticles
  • Bone metastases
  • Cementoplasty
  • Vertebroplasty
Citation (ISO format)
MOHAMED, Mohamed, BORCHARD, Gerrit, JORDAN, Olivier. In situ forming implants for local chemotherapy and hyperthermia of bone tumors. In: Journal of drug delivery science and technology, 2012, vol. 22, n° 5, p. 393–408.
Main files (1)
Article (Accepted version)
accessLevelPublic
Identifiers
  • PID : unige:24338
ISSN of the journal1773-2247
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