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Scientific article
English

Peripheral autoimmune neuropathy assessed using corneal in vivo confocal microscopy

Contributors

Lalive d'Epinay, Patrice; Truffert, André; Magistris, Michel; Landis, Theodor; Dosso, André

Published in

Archives of neurology, vol. 66, no. 3, p. 403-405

Publication date

2009

Abstract

BACKGROUND: Corneal nerves can be examined using in vivo confocal microscopy (IVCM). This new technique permits sequential observation of the corneal subbasal nerve plexus and detects early signs of diabetic peripheral neuropathy. OBJECTIVE: To describe a patient with autoimmune peripheral neuropathy followed up using corneal IVCM. DESIGN: Case report. SETTING: Clinic of neurology, Geneva, Switzerland. Patient A 56-year-old man with peripheral neuropathy diagnosed as anti-myelin-associated glycoprotein neuropathy. His symptoms initially worsened despite the administration of intravenous immunoglobulins and plasma exchange. Evolution was eventually favorable after rituximab and corticosteroids were given. At 1-year follow-up, clinical recovery was almost complete, and the patient was stable according to the results of clinical and electrophysiologic assessments. Main Outcome Measure Corneal nerve measurement by IVCM. RESULTS: Examination of corneal nerves using IVCM at 2 different times during the patient's clinical evolution (peak disease and recovery phase) demonstrated histologic signs that correlated with the results of clinical and electrophysiologic assessments. CONCLUSION: This observation supports the hypothesis that corneal IVCM could also be helpful for the early detection or follow-up of autoimmune peripheral neuropathy.

Keywords

  • Autonomic Nervous System Diseases/diagnosis/drug therapy/immunology
  • Cornea/innervation/pathology
  • Humans
  • Immunologic Factors/therapeutic use
  • Male
  • Microscopy, Confocal/methods
  • Middle Aged
  • Myelin-Associated Glycoprotein/immunology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

LALIVE D’EPINAY, Patrice et al. Peripheral autoimmune neuropathy assessed using corneal in vivo confocal microscopy. In: Archives of neurology, 2009, vol. 66, n° 3, p. 403–405. doi: 10.1001/archneurol.2008.587

Main files (1)

Article (Accepted version)

Identifiers

Additional URL for this publication

http://archneur.ama-assn.org/cgi/content/full/66/3/403

Journal ISSN

0003-9942
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Technical informations

Creation

13/08/2009 14:26:00

First validation

13/08/2009 14:26:00

Update

14/03/2023 15:10:30

Status update

14/03/2023 15:10:30

Last indexation

29/10/2024 11:53:26
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