Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms

Lagging, Martin; Askarieh, Galia; Negro, Francesco; Bibert, Stéphanie; Söderholm, Jonas; Westin, Johan; Lindh, Magnus; Romero, Ana; Missale, Gabriele; Ferrari, Carlo; Neumann, Avidan U; Pawlotsky, Jean-Michel; Haagmans, Bart L; Zeuzem, Stefan; Bochud, Pierre-Yves; Hellstrand, Kristoffer

doi:10.1371/journal.pone.0017232

Scientific article

English

Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms

ContributorsLagging, Martin; Askarieh, Galia; Negro, Francesco; Bibert, Stéphanie; Söderholm, Jonas; Westin, Johan; Lindh, Magnus; Romero, Ana; Missale, Gabriele; Ferrari, Carlo; Neumann, Avidan U; Pawlotsky, Jean-Michel; Haagmans, Bart L; Zeuzem, Stefan; Bochud, Pierre-Yves; Hellstrand, Kristoffer

Published inPloS one, vol. 6, no. 2, e17232

Publication date2011

Abstract

High baseline levels of IP-10 predict a slower first phase decline in HCV RNA and a poor outcome following interferon/ribavirin therapy in patients with chronic hepatitis C. Several recent studies report that single nucleotide polymorphisms (SNPs) adjacent to IL28B predict spontaneous resolution of HCV infection and outcome of treatment among HCV genotype 1 infected patients.

Keywords

Adult
Antiviral Agents/administration & dosage/therapeutic use
Biomarkers, Pharmacological/analysis/metabolism
Chemokine CXCL10/analysis/genetics/metabolism
Drug Administration Schedule
Female
Hepatitis C, Chronic/diagnosis/drug therapy/genetics
Humans
Interferon-alpha/administration & dosage/therapeutic use
Interleukins/analysis/genetics/metabolism
Male
Middle Aged
Pharmacogenetics
Polymorphism, Single Nucleotide/physiology
Prognosis
RNA, Viral/analysis/genetics
Recombinant Proteins

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Etudes et traitement de l'hépatite C et B (554)

Citation (ISO format)

LAGGING, Martin et al. Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms. In: PloS one, 2011, vol. 6, n° 2, p. e17232. doi: 10.1371/journal.pone.0017232

Article (Published version)

CC BY

Identifiers

PID : unige:24272
DOI : 10.1371/journal.pone.0017232
PMID : 21390311

Journal ISSN1932-6203

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Update14/03/2023 17:46:07

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Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms

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