The Ccr4-Not complex

Collart, Martine; Panasenko, Olesya

doi:10.1016/j.gene.2011.09.033

Scientific article

English

The Ccr4-Not complex

Contributors

Collart, Martine

; Panasenko, Olesya

Published in

Gene, vol. 492, no. 1, p. 42-53

Publication date

2012

Abstract

The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression. Two enzymatic activities, namely ubiquitination and deadenylation, are provided by different subunits of the complex. However, studies over the last decade have demonstrated a tantalizing multi-functionality of this complex that extends well beyond its identified enzymatic activities. Most of our initial knowledge about the Ccr4-Not complex stemmed from studies in yeast, but an increasing number of reports on this complex in other species are emerging. In this review we will discuss the structure and composition of the complex, and describe the different cellular functions with which the Ccr4-Not complex has been connected in different organisms. Finally, based upon our current state of knowledge, we will propose a model to explain how one complex can provide such multi-functionality. This model suggests that the Ccr4-Not complex might function as a "chaperone platform".

Keywords

Adenosine Monophosphate/metabolism
Animals
DNA Repair
Gene Expression Regulation
Humans
Models, Biological
Molecular Chaperones/metabolism
Receptors, CCR4/chemistry/physiology
Transcription, Genetic
Ubiquitination

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

UNIGE research groups

Caractérisation génétique et biochimique du complexe Ccr4-Not conservé (81)

Citation (ISO format)

COLLART, Martine, PANASENKO, Olesya. The Ccr4-Not complex. In: Gene, 2012, vol. 492, n° 1, p. 42–53. doi: 10.1016/j.gene.2011.09.033

Article (Published version)

Identifiers

PID : unige:24262
DOI : 10.1016/j.gene.2011.09.033
PMID : 22027279

Journal ISSN

0378-1119

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01/11/2012 13:04:00

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01/11/2012 13:04:00

Update

14/03/2023 17:46:03

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14/03/2023 17:46:03

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30/10/2024 07:58:05

The Ccr4-Not complex

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation