Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection

Lucifora, Julie; Arzberger, Silke; Durantel, David; Belloni, Laura; Strubin, Michel; Levrero, Massimo; Zoulim, Fabien; Hantz, Olivier; Protzer, Ulrike

doi:10.1016/j.jhep.2011.02.015

Scientific article

English

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection

ContributorsLucifora, Julie; Arzberger, Silke; Durantel, David; Belloni, Laura; Strubin, Michel; Levrero, Massimo; Zoulim, Fabien; Hantz, Olivier; Protzer, Ulrike

Published inJournal of hepatology, vol. 55, no. 5, p. 996-1003

Publication date2011

Abstract

The molecular biology of hepatitis B virus (HBV) has been extensively studied but the exact role of the hepatitis B X protein (HBx) in the context of natural HBV infections remains unknown.

Keywords

DNA, Circular/metabolism
DNA, Viral/metabolism
Hep G2 Cells
Hepatitis B/virology
Hepatitis B Surface Antigens/metabolism
Hepatitis B e Antigens/metabolism
Hepatitis B virus/genetics/physiology
Hepatocytes
Humans
Trans-Activators/genetics/physiology
Transcription, Genetic
Transfection
Virus Replication

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

Research groups

Régulation de l'expression des gènes du virus de l'hépatite B (294)

Funding

Swiss National Science Foundation - Part I: Dynamics of Histone Exchange and Epigenetic Modifications during Transcription in vivo Part II: Hijacking of the DDB1 Ubiquitin Ligase by the HBV X Protein: What Role during Infection and Associated Liver Cancer? [127384]

Citation (ISO format)

LUCIFORA, Julie et al. Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. In: Journal of hepatology, 2011, vol. 55, n° 5, p. 996–1003. doi: 10.1016/j.jhep.2011.02.015

Article (Published version)

Identifiers

PID : unige:24258
DOI : 10.1016/j.jhep.2011.02.015
PMID : 21376091

Additional URL for this publicationhttp://www.sciencedirect.com/science/article/pii/S0168827811001978

Journal ISSN0168-8278

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Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection

The molecular biology of hepatitis B virus (HBV) has been extensively studied but the exact role of the hepatitis B X protein (HBx) in the context of natural HBV infections remains unknown.

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