Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection

Lucifora, Julie; Arzberger, Silke; Durantel, David; Belloni, Laura; Strubin, Michel; Levrero, Massimo; Zoulim, Fabien; Hantz, Olivier; Protzer, Ulrike

doi:10.1016/j.jhep.2011.02.015

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Title		Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
Authors		Lucifora, Julie Arzberger, Silke Durantel, David Belloni, Laura Strubin, Michel Levrero, Massimo Zoulim, Fabien Hantz, Olivier Protzer, Ulrike show all authors [1 - 9]
Published in		Journal of Hepatology. 2011, vol. 55, no. 5, p. 996-1003
Abstract		The molecular biology of hepatitis B virus (HBV) has been extensively studied but the exact role of the hepatitis B X protein (HBx) in the context of natural HBV infections remains unknown.
Keywords		DNA, Circular/metabolism — DNA, Viral/metabolism — Hep G2 Cells — Hepatitis B/virology — Hepatitis B Surface Antigens/metabolism — Hepatitis B e Antigens/metabolism — Hepatitis B virus/genetics/physiology — Hepatocytes — Humans — Trans-Activators/genetics/physiology — Transcription, Genetic — Transfection — Virus Replication
Identifiers		DOI: 10.1016/j.jhep.2011.02.015 PMID: 21376091
Full text		Article (Published version) (734 Kb) - Limited access to UNIGE Other version: http://www.sciencedirect.com/science/article/pii/S0168827811001978
Structures		Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire
Research group		Régulation de l'expression des gènes du virus de l'hépatite B (294)
Project		FNS: 31003A-127384
Citation (ISO format)		LUCIFORA, Julie et al. Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. In: Journal of Hepatology, 2011, vol. 55, n° 5, p. 996-1003. doi: 10.1016/j.jhep.2011.02.015 https://archive-ouverte.unige.ch/unige:24258