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New analytical strategies in studying drug metabolism

Staack, Roland F.
Published in Analytical and Bioanalytical Chemistry. 2007, vol. 388, no. 7, p. 1365-80
Collection Open Access - Licence nationale Springer
Abstract Identification and elucidation of the structures of metabolites play major roles in drug discovery and in the development of pharmaceutical compounds. These studies are also important in toxicology or doping control with either pharmaceuticals or illicit drugs. This review focuses on: new analytical strategies used to identify potential metabolites in biological matrices with and without radiolabeled drugs; use of software for metabolite profiling; interpretation of product spectra; profiling of reactive metabolites; development of new approaches for generation of metabolites; and detection of metabolites with increased sensitivity and simplicity. Most of the new strategies involve mass spectrometry (MS) combined with liquid chromatography (LC).
Keywords Chemistry, Analytical/instrumentation/methodsChromatography, LiquidMetabolismPharmaceutical Preparations/metabolismSoftwareTandem Mass Spectrometry
PMID: 17583803
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STAACK, Roland F., HOPFGARTNER, Gerard. New analytical strategies in studying drug metabolism. In: Analytical and Bioanalytical Chemistry, 2007, vol. 388, n° 7, p. 1365-80. https://archive-ouverte.unige.ch/unige:2411

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Deposited on : 2009-08-11

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