Formation of chiral fluoroalkyl products through copper-free enantioselective allylic alkylation catalyzed by an NHC ligand

Grassi, David; Li, Hailing; Alexakis, Alexandre

doi:10.1039/c2cc36513h

Scientific article

English

Formation of chiral fluoroalkyl products through copper-free enantioselective allylic alkylation catalyzed by an NHC ligand

ContributorsGrassi, David; Li, Hailing; Alexakis, Alexandre

Published inChemical communications, vol. 48, no. 93, p. 11404-11406

Publication date2012

Abstract

A valuable Cu-free protocol is reported where an NHC ligand has been employed to form quaternary carbon centers bearing fluoroalkyl units. The results obtained, from this allylic substitution, are better in terms of enantioselectivity and regioselectivity compared to the copper catalyzed system.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

GRASSI, David, LI, Hailing, ALEXAKIS, Alexandre. Formation of chiral fluoroalkyl products through copper-free enantioselective allylic alkylation catalyzed by an NHC ligand. In: Chemical communications, 2012, vol. 48, n° 93, p. 11404–11406. doi: 10.1039/c2cc36513h

Article (Published version)

Identifiers

PID : unige:23740
DOI : 10.1039/c2cc36513h

Commercial URLhttp://xlink.rsc.org/?DOI=c2cc36513h

Journal ISSN1359-7345

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Creation01/11/2012 10:05:00

First validation01/11/2012 10:05:00

Update time14/03/2023 17:44:06

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Formation of chiral fluoroalkyl products through copper-free enantioselective allylic alkylation catalyzed by an NHC ligand

A valuable Cu-free protocol is reported where an NHC ligand has been employed to form quaternary carbon centers bearing fluoroalkyl units. The results obtained, from this allylic substitution, are better in terms of enantioselectivity and regioselectivity compared to the copper catalyzed system.

Technical informations