UNIGE document Scientific Article
previous document  unige:2370  next document
add to browser collection
Title

Evaluation of [(18)F]-choline PET/CT for staging and restaging of prostate cancer

Authors
Husarik, Daniela B.
Dubs, Markus
John, Hubert
Giger, Olivier T.
Gelet, Albert
Cservenyàk, Tibor
Hany, Thomas F.
Published in European Journal of Nuclear Medicine and Molecular Imaging. 2008, vol. 35, no. 2, p. 253-63
Abstract PURPOSE: To evaluate the accuracy of [(18)F]-choline (FCH) positron emission tomography/computed tomography (PET/CT) for staging and restaging of prostate cancer. METHODS: FCH PET/CT was performed in 111 patients with prostate cancer using 200 MBq FCH: 43 patients [mean age 63 years; mean prostrate specific antigen (PSA) 11.58 microg/l] were examined for initial staging, and 68 patients (mean age 66.4 years) were examined for restaging (mean PSA 10.81 microg/l). FCH PET/CT results were correlated to histopathology, bone scan, morphology as revealed by magnetic resonance imaging (MRI) and CT, PET/CT follow-up and PSA follow-up after therapy. RESULTS: FCH PET/CT scans at initial staging correctly showed no metastases in 36/38 patients undergoing radical surgery, as confirmed by PSA levels <0.1 microg/l 6 months postoperatively. Lymphadenectomy was performed in 24 of these patients, revealing four false FCH-negative lymph nodes (LN). In one patient, only lymphadenectomy was performed since a FCH-positive LN was confirmed by histology. Four patients showed FCH-positive bone metastases, as proven by bone scan. FCH PET/CT scans at restaging correctly revealed local recurrence in 36 patients. No pathological FCH uptake was observed in 11 patients with biochemical recurrence. Twenty-three patients showed FCH-positive LN. Twenty LN were surgically removed in seven patients. Histopathology verified metastases in all LN, but revealed two additional metastastic, FCH-negative LN. Seventeen patients showed FCH-positive bone metastases, as proven by bone scan or MRI. Sensitivity to detect recurrent disease was 86%. CONCLUSION: The results obtained using FCH PET/CT scans for initial N-staging were discouraging, especially in terms of its inability to detect small metastases. Recurrent disease can be localized reliably in patients with PSA levels of >2 microg/l.
Keywords AgedCholine/diagnostic useFluorine Radioisotopes/diagnostic useHumansMaleMiddle AgedNeoplasm StagingPositron-Emission Tomography/methodsProstatic Neoplasms/diagnosisRadiopharmaceuticals/diagnostic useReproducibility of ResultsSensitivity and SpecificityTomography, X-Ray Computed/methods
Identifiers
PMID: 17926036
Full text
Structures
Research group Groupe Mirabell Raymond (radio-oncologie) (685)
Citation
(ISO format)
HUSARIK, Daniela B. et al. Evaluation of [(18)F]-choline PET/CT for staging and restaging of prostate cancer. In: European Journal of Nuclear Medicine and Molecular Imaging, 2008, vol. 35, n° 2, p. 253-63. https://archive-ouverte.unige.ch/unige:2370

183 hits

0 download

Update

Deposited on : 2009-08-10

Export document
Format :
Citation style :