UNIGE document Professional Article
previous document  unige:23335  next document
add to browser collection
Title

Urinary proteomics and drug discovery in chronic kidney disease: a new perspective

Authors
Ghiggeri, Gian Marco
Candiano, Giovanni
Published in Journal of Proteome Research. 2011, vol. 10, no. 1, p. 126-32
Abstract Chronic kidney disease (CKD) is becoming a worldwide public health problem. The identification of a specific set of early biomarkers for CKD is extremely relevant to progress in disease knowledge, improving diagnosis, treatment, or development, and monitoring efficacy of new drugs. As kidney fibrosis can be considered the common pathological way to end stage renal failure, independent of the initial renal insult, these biomarkers are therefore biomarkers of early tubulo-interstitial fibrosis. The availability of a specific set of biomarkers for CKD is the mandatory condition to create new dedicated drugs and validate them in clinics without waiting years for a functional response in patients. We suggest here specific cohorts of patients where this early signature of fibrosis may be simpler to be identified.
Keywords Biological Markers/urineDrug Discovery/methodsFibrosis/metabolism/pathologyHistocytochemistryHumansKidney Failure, Chronic/metabolism/urineProteinuriaProteomics/methods
Identifiers
PMID: 20718506
Full text
Article (Published version) (2.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Analyse protéomique et Analyse génomique des maladies rénales (659)
Chimie et protéomique clinique (270)
Citation
(ISO format)
PRUNOTTO, Marco et al. Urinary proteomics and drug discovery in chronic kidney disease: a new perspective. In: Journal of Proteome Research, 2011, vol. 10, n° 1, p. 126-32. https://archive-ouverte.unige.ch/unige:23335

140 hits

0 download

Update

Deposited on : 2012-10-15

Export document
Format :
Citation style :