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Fragmentation of Bosentan (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy : a case of radical fragmentation of an even-electron Ion

Authors
Vetter, W.
Meister, W.
Ramuz, H.
Published in Journal of Mass Spectrometry. 1996, vol. 31, no. 1, p. 69-76
Abstract For metabolic studies the fragmentation of a novel endothelin receptor antagonist, Bosentan, was investigated using ionspray tandem mass spectrometry. Bosentan belongs to the sulphonamide class and a complicated and unexpected fragmentation at low energy, involving a radical fragmentation of an even-electron ion at the sulphonamide bond, is reported.
Keywords Ion sprayCollision induced dissociationBosentanDeuterium exchangeSulfonamide
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HOPFGARTNER, Gerard et al. Fragmentation of Bosentan (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy : a case of radical fragmentation of an even-electron Ion. In: Journal of Mass Spectrometry, 1996, vol. 31, n° 1, p. 69-76. https://archive-ouverte.unige.ch/unige:2308

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Deposited on : 2009-08-04

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