Fragmentation of Bosentan (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy : a case of radical fragmentation of an even-electron Ion

Hopfgartner, Gerard; Vetter, W.; Meister, W.; Ramuz, H.

doi:10.1002/(SICI)1096-9888(199601)31:1<69::AID-JMS264>3.0.CO;2-Q

Scientific article

English

Fragmentation of Bosentan (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy : a case of radical fragmentation of an even-electron Ion

ContributorsHopfgartner, Gerard

; Vetter, W.; Meister, W.; Ramuz, H.

Published inJournal of mass spectrometry, vol. 31, no. 1, p. 69-76

Publication date1996

Abstract

For metabolic studies the fragmentation of a novel endothelin receptor antagonist, Bosentan, was investigated using ionspray tandem mass spectrometry. Bosentan belongs to the sulphonamide class and a complicated and unexpected fragmentation at low energy, involving a radical fragmentation of an even-electron ion at the sulphonamide bond, is reported.

Keywords

Ion spray
Collision induced dissociation
Bosentan
Deuterium exchange
Sulfonamide

Affiliation

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

HOPFGARTNER, Gerard et al. Fragmentation of Bosentan (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy : a case of radical fragmentation of an even-electron Ion. In: Journal of mass spectrometry, 1996, vol. 31, n° 1, p. 69–76. doi: 10.1002/(SICI)1096-9888(199601)31:1<69::AID-JMS264>3.0.CO;2-Q

Article (Accepted version)

Identifiers

PID : unige:2308
DOI : 10.1002/(SICI)1096-9888(199601)31:1<69::AID-JMS264>3.0.CO;2-Q

ISSN of the journal1076-5174

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Fragmentation of Bosentan (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy : a case of radical fragmentation of an even-electron Ion

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