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Using controlled laser-microporation to increase transdermal delivery of prednisone

Summer, S
Heinrich, A
Bragagna, T
Böhler, C
Published in Journal of controlled release. 2010, vol. 148, no. 1, p. e71-3
Abstract The objective was to investigate whether laser microporation could enhance transdermal delivery of prednisone. Results demonstrated that transport was controlled by pore number and depth; it was substantially improved over delivery through intact skin. Prednisone delivery(permeation+deposition) across porated skin (1800 pores) after 24 h was 197.18±29.62 μg/cm2; in contrast, no transport was observed across intact skin. Increasing pore depth so that micropores reached the epidermis produced corresponding increases in prednisone transport.
Keywords Administration, CutaneousAnimalsDrug Delivery SystemsLasersPrednisone/administration & dosage/pharmacokineticsSkin/metabolismSwine
PMID: 21529638
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YU, Jing et al. Using controlled laser-microporation to increase transdermal delivery of prednisone. In: Journal of controlled release, 2010, vol. 148, n° 1, p. e71-3. doi: 10.1016/j.jconrel.2010.07.032 https://archive-ouverte.unige.ch/unige:22849

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Deposited on : 2012-09-12

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