Using controlled laser-microporation to increase transdermal delivery of prednisone

Yu, Jing; Bachhav, Yogeshwar; Summer, S; Heinrich, A; Bragagna, T; Böhler, C; Kalia, Yogeshvar

doi:10.1016/j.jconrel.2010.07.032

Scientific article

English

Using controlled laser-microporation to increase transdermal delivery of prednisone

ContributorsYu, Jing; Bachhav, Yogeshwar; Summer, S; Heinrich, A; Bragagna, T; Böhler, C; Kalia, Yogeshvar

Published inJournal of controlled release, vol. 148, no. 1, p. e71-73

Publication date2010

Abstract

The objective was to investigate whether laser microporation could enhance transdermal delivery of prednisone. Results demonstrated that transport was controlled by pore number and depth; it was substantially improved over delivery through intact skin. Prednisone delivery(permeation+deposition) across porated skin (1800 pores) after 24 h was 197.18±29.62 μg/cm2; in contrast, no transport was observed across intact skin. Increasing pore depth so that micropores reached the epidermis produced corresponding increases in prednisone transport.

Keywords

Administration, Cutaneous
Animals
Drug Delivery Systems
Lasers
Prednisone/administration & dosage/pharmacokinetics
Skin/metabolism
Swine

Affiliation

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

YU, Jing et al. Using controlled laser-microporation to increase transdermal delivery of prednisone. In: Journal of controlled release, 2010, vol. 148, n° 1, p. e71–73. doi: 10.1016/j.jconrel.2010.07.032

Extract

Identifiers

PID : unige:22849
DOI : 10.1016/j.jconrel.2010.07.032
PMID : 21529638

ISSN of the journal0168-3659

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Using controlled laser-microporation to increase transdermal delivery of prednisone

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