Scientific article

Using controlled laser-microporation to increase transdermal delivery of prednisone

Published inJournal of controlled release, vol. 148, no. 1, p. e71-73
Publication date2010

The objective was to investigate whether laser microporation could enhance transdermal delivery of prednisone. Results demonstrated that transport was controlled by pore number and depth; it was substantially improved over delivery through intact skin. Prednisone delivery(permeation+deposition) across porated skin (1800 pores) after 24 h was 197.18±29.62 μg/cm2; in contrast, no transport was observed across intact skin. Increasing pore depth so that micropores reached the epidermis produced corresponding increases in prednisone transport.

  • Administration, Cutaneous
  • Animals
  • Drug Delivery Systems
  • Lasers
  • Prednisone/administration & dosage/pharmacokinetics
  • Skin/metabolism
  • Swine
Citation (ISO format)
YU, Jing et al. Using controlled laser-microporation to increase transdermal delivery of prednisone. In: Journal of controlled release, 2010, vol. 148, n° 1, p. e71–73. doi: 10.1016/j.jconrel.2010.07.032
Secondary files (1)
ISSN of the journal0168-3659

Technical informations

Creation09/03/2012 1:55:00 PM
First validation09/03/2012 1:55:00 PM
Update time03/14/2023 5:40:35 PM
Status update03/14/2023 5:40:34 PM
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