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Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates

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Published in Pharmaceutical Research. 2004, vol. 21, no. 8, p. 1390-7
Abstract The purpose of this study was (i) to validate differentially tape-stripped, porcine skin as an in vitro model for the evaluation of transdermal drug delivery (TDD) to premature neonates, (ii) to determine whether the model could estimate neonatal skin permeability as a function of postconceptional age (PCA), and (iii) to demonstrate that iontophoretic delivery permits precise control of drug input independent of skin barrier function.
Keywords AdministrationCutaneousAge FactorsAnimalsCaffeine/pharmacokineticsDiffusionEarHumansInfantNewbornInfantPremature/metabolismIontophoresis/methodsLidocaine/pharmacokineticsModelsAnimalPermeabilityPhenobarbital/pharmacokineticsSkin/metabolismSwine
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PMID: 15359573
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SEKKAT, Nabila, KALIA, Yogeshvar, GUY, Richard H. Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates. In: Pharmaceutical Research, 2004, vol. 21, n° 8, p. 1390-7. https://archive-ouverte.unige.ch/unige:22639

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Deposited on : 2012-08-29

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