en
Scientific article
English

Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates

Published inPharmaceutical research, vol. 21, no. 8, p. 1390-1397
Publication date2004
Abstract

The purpose of this study was (i) to validate differentially tape-stripped, porcine skin as an in vitro model for the evaluation of transdermal drug delivery (TDD) to premature neonates, (ii) to determine whether the model could estimate neonatal skin permeability as a function of postconceptional age (PCA), and (iii) to demonstrate that iontophoretic delivery permits precise control of drug input independent of skin barrier function.

Keywords
  • Administration
  • Cutaneous
  • Age Factors
  • Animals
  • Caffeine/pharmacokinetics
  • Diffusion
  • Ear
  • Humans
  • Infant
  • Newborn
  • Infant
  • Premature/metabolism
  • Iontophoresis/methods
  • Lidocaine/pharmacokinetics
  • Models
  • Animal
  • Permeability
  • Phenobarbital/pharmacokinetics
  • Skin/metabolism
  • Swine
Citation (ISO format)
SEKKAT, Nabila, KALIA, Yogeshvar, GUY, Richard H. Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates. In: Pharmaceutical research, 2004, vol. 21, n° 8, p. 1390–1397. doi: 10.1023/B:PHAM.0000036912.94452.d0
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0724-8741
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Technical informations

Creation08/24/2012 9:54:00 AM
First validation08/24/2012 9:54:00 AM
Update time03/14/2023 5:39:41 PM
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