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Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking

Iseli, Hans Peter
Published in Journal of Cataract and Refractive Surgery. 2008, vol. 34, no. 7, p. 1219-21
Abstract Iatrogenic keratectasia after laser in situ keratomileusis (LASIK) represents a serious complication of refractive laser surgery. We describe a woman who developed bilateral iatrogenic keratectasia during her first pregnancy 26 months after LASIK. Corneal collagen crosslinking (CCL) with riboflavin and ultraviolet-A was performed in March 2005 (right eye) and April 2005 (left eye). This treatment stopped the progression and even caused the keratometric steepness to regress over a postoperative follow-up of 22 months, as demonstrated by preoperative and postoperative corneal topographies and maximum K-readings. During the patient's second pregnancy, the keratectasia exacerbated. To our knowledge, this is the first case showing exacerbation of keratectasia despite CCL and, as the exacerbation occurred only during pregnancy, suggesting that hormonal changes might affect corneal biomechanical stability.
Keywords AdultCollagen/metabolism/radiation effectsCornea/metabolism/pathologyCorneal Diseases/etiologyCorneal TopographyDilatation, Pathologic/etiologyFemaleHumansIatrogenic DiseaseKeratomileusis, Laser In SituLasers, Excimer/therapeutic usePhotosensitizing Agents/therapeutic usePregnancyPregnancy ComplicationsRiboflavin/therapeutic useUltraviolet Rays
PMID: 18571094
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Research group Groupe Hafezi Farhad (ophtalmologie) (912)
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HAFEZI, Farhad, ISELI, Hans Peter. Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking. In: Journal of Cataract & Refractive Surgery, 2008, vol. 34, n° 7, p. 1219-21. doi: 10.1016/j.jcrs.2008.02.036 https://archive-ouverte.unige.ch/unige:22477

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Deposited on : 2012-08-21

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