Scientific article
Case report
Open access

Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking

Published inJournal of cataract and refractive surgery, vol. 34, no. 7, p. 1219-1221
Publication date2008

Iatrogenic keratectasia after laser in situ keratomileusis (LASIK) represents a serious complication of refractive laser surgery. We describe a woman who developed bilateral iatrogenic keratectasia during her first pregnancy 26 months after LASIK. Corneal collagen crosslinking (CCL) with riboflavin and ultraviolet-A was performed in March 2005 (right eye) and April 2005 (left eye). This treatment stopped the progression and even caused the keratometric steepness to regress over a postoperative follow-up of 22 months, as demonstrated by preoperative and postoperative corneal topographies and maximum K-readings. During the patient's second pregnancy, the keratectasia exacerbated. To our knowledge, this is the first case showing exacerbation of keratectasia despite CCL and, as the exacerbation occurred only during pregnancy, suggesting that hormonal changes might affect corneal biomechanical stability.

  • Adult
  • Collagen/metabolism/radiation effects
  • Cornea/metabolism/pathology
  • Corneal Diseases/etiology
  • Corneal Topography
  • Dilatation, Pathologic/etiology
  • Female
  • Humans
  • Iatrogenic Disease
  • Keratomileusis, Laser In Situ
  • Lasers, Excimer/therapeutic use
  • Photosensitizing Agents/therapeutic use
  • Pregnancy
  • Pregnancy Complications
  • Riboflavin/therapeutic use
  • Ultraviolet Rays
Citation (ISO format)
HAFEZI, Farhad, ISELI, Hans Peter. Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking. In: Journal of cataract and refractive surgery, 2008, vol. 34, n° 7, p. 1219–1221. doi: 10.1016/j.jcrs.2008.02.036
Main files (1)
Article (Published version)
ISSN of the journal0886-3350

Technical informations

Creation08/21/2012 10:27:00 AM
First validation08/21/2012 10:27:00 AM
Update time03/14/2023 5:39:26 PM
Status update03/14/2023 5:39:26 PM
Last indexation01/16/2024 12:07:49 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack