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Molecular dissection of host cell invasion by the apicomplexans: the glideosome

Published in Parasite. 2008, vol. 15, no. 3, p. 197-205
Abstract Gliding motility is an essential and fascinating apicomplexan-typical adaptation to an intracellular lifestyle. Apicomplexan parasites rely on gliding motility for their migration across biological barriers and for host cell invasion and egress. This unusual substratedependent mode of locomotion involves the concerted action of secretory adhesins, a myosin motor, factors regulating actin dynamics and proteases. During invasion, complexes of soluble and transmembrane micronemes proteins (MICs) and rhoptry neck proteins (RONs) are discharged to the apical pole of the parasite, some protein acts as adhesins and bind to host cell receptors whereas others are involved in the moving junction formation. These complexes redistribute towards the posterior pole of the parasite via a physical connection to the parasite actomyosin system and are eventually released from the parasite surface by the action of parasite proteases.
Keywords Actomyosin/chemistry/physiologyAnimalsApicomplexa/cytology/physiology/ultrastructureCell Adhesion/physiologyCell Movement/physiologyCytoskeletonHost-Parasite InteractionsHumansMembrane Proteins/chemistry/physiologyMolecular Motor Proteins/physiologyProtozoan Infections/parasitologyProtozoan Proteins/chemistry/physiology
PMID: 18814681
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Research group Biologie d'un parasite intracellulaire obligatoire (773)
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SOLDATI-FAVRE, Dominique. Molecular dissection of host cell invasion by the apicomplexans: the glideosome. In: Parasite, 2008, vol. 15, n° 3, p. 197-205. doi: 10.1051/parasite/2008153197 https://archive-ouverte.unige.ch/unige:2236

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Deposited on : 2009-07-17

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