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Roles of proteases during invasion and egress by Plasmodium and Toxoplasma

Dowse, Timothy J.
Koussis, Konstantinos
Blackman, Michael J.
Published in Macromolecular Protein Complexes. Subcellular Biochemistry. 2008, vol. 47, p. 121-139
Abstract Apicomplexan pathogens replicate exclusively within the confines of a host cell. Entry into (invasion) and exit from (egress) these cells requires an array of specialized parasite molecules, many of which have long been considered to have potential as targets of drug or vaccine-based therapies. In this chapter the authors discuss the current state of knowledge regarding the role of parasite proteolytic enzymes in these critical steps in the life cycle of two clinically important apicomplexan genera, Plasmodium and Toxoplasma. At least three distinct proteases of the cysteine mechanistic class have been implicated in egress of the malaria parasite from cells of its vertebrate and insect host. In contrast, the bulk of the evidence indicates a prime role for serine proteases of the subtilisin and rhomboid families in invasion by both parasites. Whereas proteases involved in egress may function predominantly to degrade host cell structures, proteases involved in invasion probably act primarily as maturases and 'sheddases', required to activate and ultimately remove ligands involved in interactions with the host cell.
Keywords AnimalsHost-Parasite InteractionsHumansModels, BiologicalPeptide Hydrolases/chemistry/classification/metabolismPlasmodium/enzymology/genetics/metabolism/pathogenicityProtein Structure, TertiaryProtozoan Proteins/chemistry/metabolismToxoplasma/enzymology/genetics/metabolism/pathogenicity
PMID: 18512347
Full text
Research group Biologie d'un parasite intracellulaire obligatoire (773)
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DOWSE, Timothy J. et al. Roles of proteases during invasion and egress by Plasmodium and Toxoplasma. In: SubCellular Biochemistry, 2008, vol. 47, p. 121-139. doi: 10.1007/978-0-387-78267-6_10 https://archive-ouverte.unige.ch/unige:2234

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Deposited on : 2009-07-17

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