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Evaluation of peptide drugs targeting mitochondria and the cyclic AMP pathway in the mdx mouse, a model for Duchenne muscular dystrophy

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Reutenauer, Julie
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Defense Thèse de doctorat : Univ. Genève, 2009 - Sc. 4076 - 2009/03/27
Abstract Duchenne muscular dystrophy (DMD) is a severe muscular dystrophy, which affects approximately 1 out of 3500 male births. Starting in early childhood, the disease is characterized by progressive muscle wasting, and associated with respiratory complications and cardiac dysfunction leading to death by age 20-30. DMD is caused by the absence of the cytoskeletal protein dystrophin that is encoded by the X-chromosome (Xp21). Dystrophin is a large protein that links the extracellular matrix via a transmembrane complex of glycoproteins to the intracellular F-actin network. This ensures mechanical stability to muscle cells during contraction. Lack of dystrophin leads to muscle cell death accompanied by chronic inflammation...
Keywords Dystrophie musculairePharmacothérapieAMP cycliquePore mitochondrial de perméabilité transitoire
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URN: urn:nbn:ch:unige-22264
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REUTENAUER, Julie. Evaluation of peptide drugs targeting mitochondria and the cyclic AMP pathway in the mdx mouse, a model for Duchenne muscular dystrophy. Université de Genève. Thèse, 2009. https://archive-ouverte.unige.ch/unige:2226

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Deposited on : 2009-07-16

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