

Other version: https://journals.lww.com/investigativeradiology/Fulltext/2007/09000/Improved_Visualization_of_Vessels_and_Hepatic.7.aspx
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Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes |
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Published in | Investigative radiology. 2007, vol. 42, no. 9, p. 652-658 | |
Abstract | OBJECTIVE: The goal of this study was to determine whether iodinated liposomes are a suitable tracer for mice microvessel and liver imaging by preclinical computed tomography (CT). MATERIALS AND METHODS: Iodinated liposomes were evaluated for vessel and liver imaging. A first group of nude mice was imaged by micro-CT after i.v. injection of liposomes at 1 or 2 gI/kg body weight (b.w.) for intervals up to 24 hours. A second group of mice bearing liver micrometastases was imaged after injection of liposomes at 2 gI/kg b.w. for intervals up to 24 hours. RESULTS: Vascular enhancements of 120 +/- 8 and 322 +/- 20 Hounsfield unit (HU) were obtained after injection of liposomes at 1 or 2 gI/kg b.w., respectively. This enhancement decreased with a blood half-life of 135 +/- 10 and 86 +/- 9 minutes, respectively. Liver enhancement of 157 +/- 5 and 235 +/- 23 HU were obtained after injection of iodinated liposomes at 1 and 2 gI/kg b.w., respectively. Liver micrometastases (250 microm) were detectable after injection of iodinated liposomes at 2 gI/kg b.w. CONCLUSIONS: Iodinated liposomes are a suitable contrast agent for vessels and liver imaging by micro-CT allowing clear vascular enhancement and detection of small liver metastases. | |
Keywords | Animals — Cell Line, Tumor — Drug Carriers/chemistry — Female — Humans — Image Enhancement/methods — Iodine/chemistry/diagnostic use — Liposomes/chemistry — Liver/blood supply/radiography — Liver Neoplasms/blood supply/radiography — Mice — Mice, Nude — Microcirculation/radiography — Neovascularization, Pathologic/radiography — Tomography, X-Ray Computed/methods/veterinary | |
Identifiers | PMID: 17700281 | |
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![]() ![]() Other version: https://journals.lww.com/investigativeradiology/Fulltext/2007/09000/Improved_Visualization_of_Vessels_and_Hepatic.7.aspx |
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Structures |
Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences |
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Research groups | Groupe Geissbuhler Antoine (informatique médicale) (222) Imagerie cardiaque fonctionnelle (541) | |
Citation (ISO format) | MONTET, Xavier Cédric Rodolphe et al. Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes. In: Investigative radiology, 2007, vol. 42, n° 9, p. 652-658. doi: 10.1097/RLI.0b013e31805f445b https://archive-ouverte.unige.ch/unige:2196 |