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Title

Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes
Authors
Montet, Xavier Cédric Rodolphe
Pastor, Catherine
Vallée, Jean-Paul
Becker, Christoph
Geissbuhler, Antoine
Morel, Denis
Meda, Paolo
Published in Investigative Radiology. 2007, vol. 42, no. 9, p. 652-658
Abstract OBJECTIVE: The goal of this study was to determine whether iodinated liposomes are a suitable tracer for mice microvessel and liver imaging by preclinical computed tomography (CT). MATERIALS AND METHODS: Iodinated liposomes were evaluated for vessel and liver imaging. A first group of nude mice was imaged by micro-CT after i.v. injection of liposomes at 1 or 2 gI/kg body weight (b.w.) for intervals up to 24 hours. A second group of mice bearing liver micrometastases was imaged after injection of liposomes at 2 gI/kg b.w. for intervals up to 24 hours. RESULTS: Vascular enhancements of 120 +/- 8 and 322 +/- 20 Hounsfield unit (HU) were obtained after injection of liposomes at 1 or 2 gI/kg b.w., respectively. This enhancement decreased with a blood half-life of 135 +/- 10 and 86 +/- 9 minutes, respectively. Liver enhancement of 157 +/- 5 and 235 +/- 23 HU were obtained after injection of iodinated liposomes at 1 and 2 gI/kg b.w., respectively. Liver micrometastases (250 microm) were detectable after injection of iodinated liposomes at 2 gI/kg b.w. CONCLUSIONS: Iodinated liposomes are a suitable contrast agent for vessels and liver imaging by micro-CT allowing clear vascular enhancement and detection of small liver metastases.
Keywords Animals — Cell Line, Tumor — Drug Carriers/chemistry — Female — Humans — Image Enhancement/methods — Iodine/chemistry/diagnostic use — Liposomes/chemistry — Liver/blood supply/radiography — Liver Neoplasms/blood supply/radiography — Mice — Mice, Nude — Microcirculation/radiography — Neovascularization, Pathologic/radiography — Tomography, X-Ray Computed/methods/veterinary
Identifiers
PMID: 17700281
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Other version: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00004424-200709000-00007&LSLINK=80&D=ovft
Structures
Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie et soins intensifs
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Citation
(ISO format) 		MONTET, Xavier Cédric Rodolphe et al. Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes. In: Investigative Radiology, 2007, vol. 42, n° 9, p. 652-658. https://archive-ouverte.unige.ch/unige:2196

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Deposited on : 2009-07-02

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