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Title

Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes
Authors
Montet, Xavier Cédric Rodolphe
Pastor, Catherine
Vallée, Jean-Paul
Becker, Christoph
Geissbuhler, Antoine
Morel, Denis
Meda, Paolo
Published in Investigative Radiology. 2007, vol. 42, no. 9, p. 652-658
Abstract OBJECTIVE: The goal of this study was to determine whether iodinated liposomes are a suitable tracer for mice microvessel and liver imaging by preclinical computed tomography (CT). MATERIALS AND METHODS: Iodinated liposomes were evaluated for vessel and liver imaging. A first group of nude mice was imaged by micro-CT after i.v. injection of liposomes at 1 or 2 gI/kg body weight (b.w.) for intervals up to 24 hours. A second group of mice bearing liver micrometastases was imaged after injection of liposomes at 2 gI/kg b.w. for intervals up to 24 hours. RESULTS: Vascular enhancements of 120 +/- 8 and 322 +/- 20 Hounsfield unit (HU) were obtained after injection of liposomes at 1 or 2 gI/kg b.w., respectively. This enhancement decreased with a blood half-life of 135 +/- 10 and 86 +/- 9 minutes, respectively. Liver enhancement of 157 +/- 5 and 235 +/- 23 HU were obtained after injection of iodinated liposomes at 1 and 2 gI/kg b.w., respectively. Liver micrometastases (250 microm) were detectable after injection of iodinated liposomes at 2 gI/kg b.w. CONCLUSIONS: Iodinated liposomes are a suitable contrast agent for vessels and liver imaging by micro-CT allowing clear vascular enhancement and detection of small liver metastases.
Keywords Animals — Cell Line, Tumor — Drug Carriers/chemistry — Female — Humans — Image Enhancement/methods — Iodine/chemistry/diagnostic use — Liposomes/chemistry — Liver/blood supply/radiography — Liver Neoplasms/blood supply/radiography — Mice — Mice, Nude — Microcirculation/radiography — Neovascularization, Pathologic/radiography — Tomography, X-Ray Computed/methods/veterinary
Identifiers
PMID: 17700281
Full text
Article (Published version) (1.5 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: https://journals.lww.com/investigativeradiology/Fulltext/2007/09000/Improved_Visualization_of_Vessels_and_Hepatic.7.aspx
Structures
Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups Imagerie cardiaque fonctionnelle (541)
Groupe Geissbuhler Antoine (informatique médicale) (222)
Citation
(ISO format) 		MONTET, Xavier Cédric Rodolphe et al. Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes. In: Investigative Radiology, 2007, vol. 42, n° 9, p. 652-658. doi: 10.1097/RLI.0b013e31805f445b https://archive-ouverte.unige.ch/unige:2196

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Deposited on : 2009-07-02

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