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Title

Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes

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Published in Investigative Radiology. 2007, vol. 42, no. 9, p. 652-658
Abstract OBJECTIVE: The goal of this study was to determine whether iodinated liposomes are a suitable tracer for mice microvessel and liver imaging by preclinical computed tomography (CT). MATERIALS AND METHODS: Iodinated liposomes were evaluated for vessel and liver imaging. A first group of nude mice was imaged by micro-CT after i.v. injection of liposomes at 1 or 2 gI/kg body weight (b.w.) for intervals up to 24 hours. A second group of mice bearing liver micrometastases was imaged after injection of liposomes at 2 gI/kg b.w. for intervals up to 24 hours. RESULTS: Vascular enhancements of 120 +/- 8 and 322 +/- 20 Hounsfield unit (HU) were obtained after injection of liposomes at 1 or 2 gI/kg b.w., respectively. This enhancement decreased with a blood half-life of 135 +/- 10 and 86 +/- 9 minutes, respectively. Liver enhancement of 157 +/- 5 and 235 +/- 23 HU were obtained after injection of iodinated liposomes at 1 and 2 gI/kg b.w., respectively. Liver micrometastases (250 microm) were detectable after injection of iodinated liposomes at 2 gI/kg b.w. CONCLUSIONS: Iodinated liposomes are a suitable contrast agent for vessels and liver imaging by micro-CT allowing clear vascular enhancement and detection of small liver metastases.
Keywords AnimalsCell Line, TumorDrug Carriers/chemistryFemaleHumansImage Enhancement/methodsIodine/chemistry/diagnostic useLiposomes/chemistryLiver/blood supply/radiographyLiver Neoplasms/blood supply/radiographyMiceMice, NudeMicrocirculation/radiographyNeovascularization, Pathologic/radiographyTomography, X-Ray Computed/methods/veterinary
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PMID: 17700281
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Research groups Imagerie cardiaque fonctionnelle (541)
Groupe Geissbuhler Antoine (informatique médicale) (222)
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MONTET, Xavier Cédric Rodolphe et al. Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes. In: Investigative Radiology, 2007, vol. 42, n° 9, p. 652-658. doi: 10.1097/RLI.0b013e31805f445b https://archive-ouverte.unige.ch/unige:2196

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Deposited on : 2009-07-02

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