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Title

Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability

Authors
Ayala-Bravo, Hilda A
Cornejo-Bravo, José M
Ganem Quintanar, Adriana
Published in Pharmaceutical Research. 2003, vol. 20, no. 8, p. 1267-73
Abstract The purpose of this work was to 1) investigate the effect of sucrose esters (sucrose oleate and sucrose laureate in water or in Transcutol, TC) on the stratum corneum (SC) barrier properties in vivo and 2) examine the impact of these surfactant-like molecules on the in vivo percutaneous penetration of a model penetrant 4-hydroxybenzonitrile (4-HB).
Keywords AdultEpidermis/drug effects/metabolismEstersFemaleHumansModels, BiologicalPermeabilityPharmaceutical VehiclesPhenols/pharmacokineticsSkin Absorption/drug effectsSolubilitySpectroscopy, Fourier Transform InfraredSucrose/analogs & derivatives/pharmacology
Identifiers
PMID: 12948025
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AYALA-BRAVO, Hilda A et al. Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability. In: Pharmaceutical Research, 2003, vol. 20, n° 8, p. 1267-73. https://archive-ouverte.unige.ch/unige:21949

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Deposited on : 2012-08-06

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