Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability

Ayala-Bravo, Hilda A; Quintanar Guerrero, David; Naik, Aarti; Kalia, Yogeshvar; Cornejo-Bravo, José M; Ganem Quintanar, Adriana

doi:10.1023/A:1025013401471

Scientific article

English

Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability

ContributorsAyala-Bravo, Hilda A; Quintanar Guerrero, David; Naik, Aarti; Kalia, Yogeshvar

; Cornejo-Bravo, José M; Ganem Quintanar, Adriana

Published inPharmaceutical research, vol. 20, no. 8, p. 1267-1273

Publication date2003

Abstract

The purpose of this work was to 1) investigate the effect of sucrose esters (sucrose oleate and sucrose laureate in water or in Transcutol, TC) on the stratum corneum (SC) barrier properties in vivo and 2) examine the impact of these surfactant-like molecules on the in vivo percutaneous penetration of a model penetrant 4-hydroxybenzonitrile (4-HB).

Keywords

Adult
Epidermis/drug effects/metabolism
Esters
Female
Humans
Models, Biological
Permeability
Pharmaceutical Vehicles
Phenols/pharmacokinetics
Skin Absorption/drug effects
Solubility
Spectroscopy, Fourier Transform Infrared
Sucrose/analogs & derivatives/pharmacology

Affiliation

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

AYALA-BRAVO, Hilda A et al. Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability. In: Pharmaceutical research, 2003, vol. 20, n° 8, p. 1267–1273. doi: 10.1023/A:1025013401471

Article (Published version)

Identifiers

PID : unige:21949
DOI : 10.1023/A:1025013401471
PMID : 12948025

Commercial URLhttp://www.springerlink.com/content/l2202r4323244768/

ISSN of the journal0724-8741

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Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability

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