en
Scientific article
English

Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability

Published inPharmaceutical research, vol. 20, no. 8, p. 1267-1273
Publication date2003
Abstract

The purpose of this work was to 1) investigate the effect of sucrose esters (sucrose oleate and sucrose laureate in water or in Transcutol, TC) on the stratum corneum (SC) barrier properties in vivo and 2) examine the impact of these surfactant-like molecules on the in vivo percutaneous penetration of a model penetrant 4-hydroxybenzonitrile (4-HB).

Keywords
  • Adult
  • Epidermis/drug effects/metabolism
  • Esters
  • Female
  • Humans
  • Models, Biological
  • Permeability
  • Pharmaceutical Vehicles
  • Phenols/pharmacokinetics
  • Skin Absorption/drug effects
  • Solubility
  • Spectroscopy, Fourier Transform Infrared
  • Sucrose/analogs & derivatives/pharmacology
Citation (ISO format)
AYALA-BRAVO, Hilda A et al. Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability. In: Pharmaceutical research, 2003, vol. 20, n° 8, p. 1267–1273. doi: 10.1023/A:1025013401471
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Article (Published version)
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Identifiers
ISSN of the journal0724-8741
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