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Scientific article
English

Significant Asymmetric Amplification in Enantioselective Cu/DiPPAM-catalyzed 1,6- and 1,4-Conjugate Additions of Diethylzinc to (Di)enones

Published inOrganic letters, vol. 14, no. 14, p. 3576-3579
Publication date2012
Abstract

An unprecedented and strong positive nonlinear effect (NLE) was observed in Cu/DiPPAM-catalyzed asymmetric 1,6-conjugate addition of Et2Zn on (E)-3-(prop-1-en-1-yl)cyclohex-2-enone (71% ee reached with a 40% ee ligand). Moreover, similar behaviors were observed in Cu/DiPPAM-catalyzed 1,4-asymmetric conjugate additions of Et2Zn on both cyclohexenone and (E)-3-non-3-en-2-one (83% and 70% ee, respectively, reached with a 40% ee ligand).

Citation (ISO format)
MAGREZ, Magaly et al. Significant Asymmetric Amplification in Enantioselective Cu/DiPPAM-catalyzed 1,6- and 1,4-Conjugate Additions of Diethylzinc to (Di)enones. In: Organic letters, 2012, vol. 14, n° 14, p. 3576–3579. doi: 10.1021/ol300866p
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ISSN of the journal1523-7052
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Creation07/20/2012 9:10:00 AM
First validation07/20/2012 9:10:00 AM
Update time03/14/2023 5:38:42 PM
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