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Significant Asymmetric Amplification in Enantioselective Cu/DiPPAM-catalyzed 1,6- and 1,4-Conjugate Additions of Diethylzinc to (Di)enones

Authors
Magrez, Magaly
Wencel-Delord, Joanna
Crévisy, Christophe
Mauduit, Marc
Published in Organic Letters. 2012, vol. 14, no. 14, p. 3576-3579
Abstract An unprecedented and strong positive nonlinear effect (NLE) was observed in Cu/DiPPAM-catalyzed asymmetric 1,6-conjugate addition of Et2Zn on (E)-3-(prop-1-en-1-yl)cyclohex-2-enone (71% ee reached with a 40% ee ligand). Moreover, similar behaviors were observed in Cu/DiPPAM-catalyzed 1,4-asymmetric conjugate additions of Et2Zn on both cyclohexenone and (E)-3-non-3-en-2-one (83% and 70% ee, respectively, reached with a 40% ee ligand).
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Other version: http://pubs.acs.org/doi/abs/10.1021/ol300866p
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MAGREZ, Magaly et al. Significant Asymmetric Amplification in Enantioselective Cu/DiPPAM-catalyzed 1,6- and 1,4-Conjugate Additions of Diethylzinc to (Di)enones. In: Organic Letters, 2012, vol. 14, n° 14, p. 3576-3579. https://archive-ouverte.unige.ch/unige:21934

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Deposited on : 2012-07-23

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